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Keywords: Raf
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Articles
Biochem Soc Trans (2021) 49 (1): 237–251.
Published: 24 December 2020
...Frazer A. Cook; Simon J. Cook The RAS-regulated RAF–MEK1/2–ERK1/2 pathway promotes cell proliferation and survival and RAS and BRAF proteins are commonly mutated in cancer. This has fuelled the development of small molecule kinase inhibitors including ATP-competitive RAF inhibitors. Type I and type...
Articles
Biochem Soc Trans (2014) 42 (4): 784–790.
Published: 11 August 2014
...Pablo G. Jambrina; Olga Bohuszewicz; Nicolae-Viorel Buchete; Walter Kolch; Edina Rosta Protein phosphorylation is one of the most common post-translational modifications in cell regulatory mechanisms. Dimerization plays also a crucial role in the kinase activity of many kinases, including RAF, CDK2...
Includes: Supplementary data
Articles
Biochem Soc Trans (2013) 41 (4): 981–986.
Published: 18 July 2013
... by the adenine ring of ATP. In the present paper, we show how the spine concept can be applied to B-Raf, specifically to engineer a kinase-dead pseudokinase. To achieve this, we mutated one of the C-spine residues in the N-lobe (N-terminal lobe), Ala 481 , to phenylalanine. This mutant cannot bind ATP...
Articles
Biochem Soc Trans (2013) 41 (4): 987–994.
Published: 18 July 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 Ca 2+ /calmodulin-activated serine kinase (CASK) human epidermal growth factor receptor 3 (Her3) kinase suppressor of Ras (KSR) mitogen-activated protein kinase (MAPK) extracellular-signal-regulated kinase pseudokinase Raf...
Articles
Biochem Soc Trans (2012) 40 (1): 67–72.
Published: 19 January 2012
... cues. This has been particularly elucidated for the Ras/Raf/MEK [mitogen-activated growth factor/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling pathway with a number of studies in fibroblasts showing that sustained ERK signalling is a requirement for S-phase entry, whereas transient...