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Biochem Soc Trans (2020) 48 (6): 2703–2719.
Published: 16 November 2020
... 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer guanine nucleotide exchange factor molecular basis of health and disease Rac Tiam1/STEF T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) and Tiam2...
Biochem Soc Trans (2020) 48 (5): 2213–2227.
Published: 11 September 2020
... Society under a transformative agreement with JISC. Cdc42 G-proteins Rac Rho-family signal transducers and activators of transcription transcription factors The Ras superfamily of small GTPases comprises over 150 biological molecular switches. These proteins are capable of switching...
Victoria Casado-Medrano, Martin J. Baker, Cynthia Lopez-Haber, Mariana Cooke, Shaofei Wang, Maria J. Caloca, Marcelo G. Kazanietz
Biochem Soc Trans (2018) 46 (4): 1003–1012.
Published: 31 July 2018
..., deregulated degradation, and/or anomalous intracellular localization. More recently, cancer-associated gain-of-function mutations in Rac1 have been identified which contribute to tumor phenotypes and confer resistance to targeted therapies. Deregulated expression/activity of Rac guanine nucleotide exchange...
Biochem Soc Trans (2018) 46 (3): 741–760.
Published: 05 June 2018
... in the tumors that have been sequenced so far ( Figure 2A ). Taking together, these observations suggest that we are only seeing the tip of the iceberg regarding the implication of RHO-dependent pathways in tumor suppression. CDC42 GTPase RAC RHO RHO GAP RHO GEF The 18 RHO GTPases present...
Biochem Soc Trans (2012) 40 (6): 1378–1382.
Published: 21 November 2012
..., and the dysregulation of Rho GTPases is associated with numerous human diseases and disorders. 1 email email@example.com 24 4 2012 © 2012 The Authors Journal 2012 actin cytoskeleton Cdc42 GTPase Rac Rho Rho GTPases constitute one of the five distinct families of the Ras superfamily...
Biochem Soc Trans (2005) 33 (4): 631–634.
Published: 01 August 2005
... of the role of Rho-family GTPases in the cell structure. Cdc42 fluorescence resonance energy transfer (FRET) GTPase-activating protein (GAP) imaging Rac Rho Rho-family GTPases function as critical molecular switches in transducing extracellular signals to the cytoskeleton [ 1 , 2...