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Keywords: Rac
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Biochem Soc Trans (2023) 51 (4): 1545–1558.
Published: 28 July 2023
... and signalling. Other important Norbin interactors are the Rac guanine-nucleotide exchange factor P-Rex1 and protein kinase A. Downstream signalling pathways regulated by Norbin include ERK, Ca 2+ and the small GTPase Rac. Here, we review the current understanding of Norbin structure, expression and its roles...
Biochem Soc Trans (2020) 48 (6): 2703–2719.
Published: 16 November 2020
... 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer guanine nucleotide exchange factor molecular basis of health and disease Rac Tiam1/STEF T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) and Tiam2...
Biochem Soc Trans (2020) 48 (5): 2213–2227.
Published: 11 September 2020
... Society under a transformative agreement with JISC. Cdc42 G-proteins Rac Rho-family signal transducers and activators of transcription transcription factors The Ras superfamily of small GTPases comprises over 150 biological molecular switches. These proteins are capable of switching...
Biochem Soc Trans (2018) 46 (3): 741–760.
Published: 05 June 2018
... ], the regulation of the YAP/TAZ pathway [ 115 ], and the engagement of pathways that evade the antitumoral immune responses [ 116 ]. Other interesting protumorigenic actions include the PAK-mediated enhancement of the signaling output from the RAS–ERK and RAS–PI3K pathways [ 47 , 117 , 118 ]. The activity of RAC...
Biochem Soc Trans (2012) 40 (6): 1378–1382.
Published: 21 November 2012
..., and the dysregulation of Rho GTPases is associated with numerous human diseases and disorders. actin cytoskeleton Cdc42 GTPase Rac Rho Rho GTPases constitute one of the five distinct families of the Ras superfamily [ 1 ]. Rho itself was discovered serendipitously in 1985 as a Ras-related protein ( R...
Biochem Soc Trans (2005) 33 (4): 631–634.
Published: 01 August 2005
... to induce neurites during neuronal development, as has been seen in the induction of membrane ruffles. Cdc42 fluorescence resonance energy transfer (FRET) GTPase-activating protein (GAP) imaging Rac Rho Rho-family GTPases function as critical molecular switches in transducing extracellular...