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Keywords: Rac
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Articles
Biochem Soc Trans (2020) 48 (6): 2703–2719.
Published: 16 November 2020
... 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer guanine nucleotide exchange factor molecular basis of health and disease Rac Tiam1/STEF T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) and Tiam2...
Articles
Biochem Soc Trans (2020) 48 (5): 2213–2227.
Published: 11 September 2020
... Society under a transformative agreement with JISC. Cdc42 G-proteins Rac Rho-family signal transducers and activators of transcription transcription factors The Ras superfamily of small GTPases comprises over 150 biological molecular switches. These proteins are capable of switching...
Articles
Biochem Soc Trans (2018) 46 (4): 1003–1012.
Published: 31 July 2018
..., deregulated degradation, and/or anomalous intracellular localization. More recently, cancer-associated gain-of-function mutations in Rac1 have been identified which contribute to tumor phenotypes and confer resistance to targeted therapies. Deregulated expression/activity of Rac guanine nucleotide exchange...
Articles
Biochem Soc Trans (2018) 46 (3): 741–760.
Published: 05 June 2018
... in the tumors that have been sequenced so far ( Figure 2A ). Taking together, these observations suggest that we are only seeing the tip of the iceberg regarding the implication of RHO-dependent pathways in tumor suppression. CDC42 GTPase RAC RHO RHO GAP RHO GEF The 18 RHO GTPases present...
Articles
Biochem Soc Trans (2012) 40 (6): 1378–1382.
Published: 21 November 2012
..., and the dysregulation of Rho GTPases is associated with numerous human diseases and disorders. 1 email halla@mskcc.org 24 4 2012 © 2012 The Authors Journal 2012 actin cytoskeleton Cdc42 GTPase Rac Rho Rho GTPases constitute one of the five distinct families of the Ras superfamily...
Articles
Biochem Soc Trans (2005) 33 (4): 631–634.
Published: 01 August 2005
... of the role of Rho-family GTPases in the cell structure. Cdc42 fluorescence resonance energy transfer (FRET) GTPase-activating protein (GAP) imaging Rac Rho Rho-family GTPases function as critical molecular switches in transducing extracellular signals to the cytoskeleton [ 1 , 2...