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Keywords: Rab7
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Articles
Biochem Soc Trans (2012) 40 (6): 1368–1372.
Published: 21 November 2012
... tendon reflexes at ankles, weakness in the lower limbs and muscle atrophy, complicated by ulcerations that often lead to amputations. Four missense mutations in the gene encoding the small GTPase Rab7 cause the CMT2B neuropathy. Rab7 is a ubiquitous protein that regulates transport to late endosomes...
Articles
Biochem Soc Trans (2009) 37 (5): 1027–1031.
Published: 21 September 2009
... missense mutations in the rab7 gene have been identified as causative of the disease. Rab7 is a small G-protein of the Rab family that controls vesicular transport to late endosomes and lysosomes in the endocytic pathway. The CMT2B-associated mutant Rab7 proteins show altered nucleotide dissociation rates...
Articles
Biochem Soc Trans (2005) 33 (4): 606–608.
Published: 01 August 2005
...@tuebingen.mpg.de ). 9 3 2005 © 2005 The Biochemical Society 2005 Caenorhabditis elegans endocytosis Rab7 r eceptor- m ediated e ndocytosis defective ( rme ) screen SAND family vacuole Endocytosis is a key process conserved in all eukaryotes. It is essential for the uptake...
Articles
Biochem Soc Trans (2005) 33 (1): 225–227.
Published: 01 February 2005
... suppressor pathway. Preliminary data suggest that Rab7, a GTPase required for transporter degradation, functions as a tumour suppressor protein, as inhibiting Rab7 activity promotes colony formation in soft agar. These studies indicate that drugs affecting this pathway might have utility as anti-cancer...