... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ciliogenesis LRRK2 lysosome Parkinson's disease phosphorylation/dephosphorylation Rab protein Parkinson's...

... 11 2016 11 11 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 GDI GEF leucine-rich repeat kinase Rab protein REP vesicular trafficking Importantly, the observation that Rab12 is a poor LRRK2 kinase substrate...

... phosphorylation Rab protein vesicle transport Parkinson's disease (PD) is a common neurodegenerative disorder of largely unknown aetiology, with ageing as a major risk factor [ 1 ]. Over a decade ago, mutations in the Leucine-Rich Repeat kinase 2 ( LRRK2 ) gene were reported to cause autosomal...

... neurodegeneration remain unclear. LRRK2 seems to regulate a variety of intracellular vesicular trafficking events to and from the late endosome in a manner dependent on various Rab proteins. At least some of those events are further regulated by LRRK2 in a manner dependent on two-pore channels (TPCs). TPCs...

.... However, attempts to classify the encoded protein on the basis of phylogeny and active conformation have not provided any clues as to its function [ 17 , 28 ]. It has been suggested in the literature that Rab18 is one of a group of Rab proteins with a putative exocytotic role [ 29 , 30 ]. However...

... © 2012 Biochemical Society 2012 calcium signalling endolysosome leucine-rich repeat kinase 2 (LRRK2) nicotinic acid–adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein LRRK2: Function and Dysfunction: A Biochemical Society Focused Meeting held at Royal...

... Journal compilation © 2011 Biochemical Society 2011 early endosome endosomal sorting motor protein Rab protein sorting nexin (SNX) Eukaryotic cells are compartmentalized into distinct organelles that are composed of specific cohorts of proteins and lipids. Precise transport mechanisms...

... in view of the fact that Rab7 is a ubiquitous protein. The present review discusses possible molecular mechanisms underlying CMT2B. © The Authors Journal compilation © 2009 Biochemical Society 2009 Charcot–Marie–Tooth disease endocytosis neurite outgrowth neurodegeneration Rab7 Rab protein...

... as within endosomal domains requires efficient systems for cholesterol sorting and recycling from different stations. The mechanisms by which this is achieved are beginning to emerge. cholesterol endosomal sterol-binding protein lysosomal storage disease Rab protein sterol transport © 2006...