...Ulrike Bräuer; Emanuela Zaharieva; Matthias Soller ELAV (embryonic lethal/abnormal visual system)/Hu proteins comprise a family of highly related neuronal RBPs (RNA-binding proteins) involved in many aspects of mRNA processing. Although they bind to highly similar short sequence motifs, they have...

.... Additional eIF4E-binding proteins have been identified in the last 10–15 years, characterized by the YXXXXLϕ motif, and by interactions (many of which remain to be detailed) with RNA-binding proteins, or other factors in complexes that recognize the specific mRNAs. In the present article, we focus...

..., suggest a role for polyQ/N regions in RNA granule assembly. low-sequence-complexity region (LSCR) polyQ/(N) region aggregation RNA-binding protein RNA granule In the cell, mRNA molecules are associated with RBPs (RNA-binding proteins) and ncRNAs (non-coding RNAs) to form RNPs...

... and plays a key role in the transport of cargo to the plasma membrane. Its cargo includes cell-surface receptors, pigment and organelles such as the endoplasmic reticulum. It is also emerging that RNA and RNA-BPs (RNA-binding proteins) make up another class of myosin Va cargo. It has long been established...

... together of adjacent exons, the presence of RNA secondary structures important for the release of one specific variable exon from the repressed state and combinatorial interaction of RNA-binding proteins for choosing a specific exon. 1 To whom correspondence should be addressed (email m.soller...

.... Sohn S.Y. Cho Y. Zhang B.T. Kim V.N. Molecular basis for the recognition of primary microRNAs by the Drosha–DGCR8 complex Cell 2006 125 887 901 30 Guil S. Caceres J.F. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a Nat...

...Florencia Cano; Diego Miranda-Saavedra; Paul J. Lehner Non-coding RNAs and their interaction with RNA-binding proteins regulate mRNA levels in key cellular processes. This has intensified interest in post-transcriptional regulation. Recent studies on the turnover of AU-rich cytokine mRNAs have...

... integrated and quantitative method to measure post-transcriptional regulation (FunREG) hepatocellular carcinoma microRNA (miRNA) mRNA post-transcriptional regulation RNA-binding protein Post-transcriptional regulation is a set of biological processes controlling cell transcripts from their birth...

...Yilei Liu; David J. Elliott Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping...

... control involve RNA-binding proteins and miRNAs (microRNAs). The TTP(tristetraprolin) family of proteins recognize and bind AU-rich elements. Deletion of TTP led to a systemic autoimmune syndrome with excess circulating TNFα (tumour necrosis factor α) and GM-CSF (granulocyte/macrophage colony-stimulating...

...Kirsty Sawicka; Martin Bushell; Keith A. Spriggs; Anne E. Willis PTB (polypyrimidine-tract-binding protein) is a ubiquitous RNA-binding protein. It was originally identified as a protein with a role in splicing but it is now known to function in a large number of diverse cellular processes...

... the exosome and a 5′–3′-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation...

... RNA-binding protein 3′-untranslated region The localization of mRNAs to different compartments of the cell allows the synthesis of proteins near to where they are required. Some mRNAs, such as those encoding β-actin and myelin basic protein, are transported to the cell periphery [ 1 , 2...