... nucleic acids oxidative damage psychiatric disorders RNA surveillance In contrast with DNA, oxidative RNA damage has not been in the major focus of research until recently, which is presumably due to the assumed transient nature of RNA. However, RNAs including messenger RNA (mRNA) can persist...

... and snoRNA (small nucleolar RNA). 1 Correspondence may be addressed to either author ( takashi.miki@fmi.ch or helge.grosshans@fmi.ch ) 9 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 RNA biogenesis RNA surveillance RNA turnover transcription...

... recognized as aberrant by the RNA surveillance machinery. The exosome, a conserved multiprotein complex containing two nucleases, is involved in both the 3′ processing and the turnover of many RNAs in the cell. A series of factors, including the TRAMP (Trf4–Air2–Mtr4 polyadenylation) complex, Mpp6 and Rrp47...

... control by RNA surveillance systems. Alternatively, mRNAs may be subject to regulated degradation, often mediated by cis -encoded determinants in the mRNA sequence that, through the recruitment of trans factors, determine the fate of the mRNA. The aim of the present review is to highlight mechanisms...

... mRNA decay RNA surveillance translation-termination codon Eukaryotic cells possess a number of surveillance mechanisms that monitor different steps during gene expression and collectively ensure sufficiently high fidelity in expressing genetic information to allow for complex forms of life...