...Katherine L.B. Borden Typically, cancer is thought to arise due to DNA mutations, dysregulated transcription and/or aberrant signalling. Recently, it has become clear that dysregulated mRNA processing, mRNA export and translation also contribute to malignancy. RNA processing events result in major...

.... 1 To whom correspondence should be addressed (email miriam.sanso@mssm.edu ). 8 10 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cyclin-dependent kinase (CDK) fission yeast histone mark RNA polymerase II transcription RNA processing...

... regularly interspaced short palindromic repeats (CRISPR) RNA processing RNA-Seq The CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated) defence systems facilitate prokaryotic immunity against invading genetic elements [ 1 – 3 ]. Genomic CRISPR loci comprise...

... role in RNA processing/degradation and discuss important new insights into exosome composition and function in human cells. 1 To whom correspondence should be addressed (email n.j.watkins@ncl.ac.uk ). 2 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012...

... splicing gene expression human papillomavirus (HPV) RNA processing serine/arginine-rich splicing factor (SRSF) virus life cycle Papillomaviruses are small non-enveloped viruses that infect various animals, including mammals. They have strict tissue tropism and host specificity: thus HPVs...

... correspondence should be addressed (email b.mueller@abdn.ac.uk ). 20 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell cycle DNA replication histone gene expression RNA degradation RNA processing translation The packaging of DNA into chromosomes...

... termination codon (PTC) RNA decay RNA processing RNA quality control NMD is a conserved mRNA surveillance pathway that eliminates aberrant transcripts containing a PTC (premature termination codon) that can arise accidentally through various means, including gene mutation, aberrant mRNA splicing...

... obtained following extensive (4 h) incubation at the non-permissive temperature, and SRP RNA is also present in increased amounts at much shorter time points, suggesting a direct, rather than potentially indirect, effect ( Figure 1 ). exosome La nuclease RNA processing signal recognition particle...

... ancestor with a diverse set of spliced leader RNA genes. eukaryote gene expression metazoan RNA processing RNA splicing SL trans -splicing in C. elegans is the subject of several excellent reviews [ 35 – 37 ]. Approx. 70% of C. elegans mRNAs are subject to SL trans -splicing to one of two...

.../SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability. This pattern of promoter recruitment was also observed at the c-Myc and Skp2 promoters but not at other NF-κB target genes [ 32 ]. So, while this mechanism of regulation is not restricted to cyclin...

... promoter-specific recognition of the 3′-box RNA processing signal requires a novel phosphorylation mark on the pol II CTD. This new mark plays a critical role in the recruitment of the snRNA gene-specific RNA-processing complex, Integrator. These new findings provide the first example of a phosphorylation...

... -Ser 5 -Pro 6 -Ser 7 . This domain is now known to play a major role in the processes of transcription and co-transcriptional RNA processing in expression of both snRNA and protein-coding genes. The heptapeptide repeat unit can be extensively modified in vivo and covalent modifications of the CTD...

.... 1 To whom correspondence should be addressed (email prabs_rajan@yahoo.co.uk ). 21 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cancer cell cycle RNA processing signal transducer and activator of RNA (STAR) Src-associated in mitosis 68 kDa (Sam68...

... exist to prevent their expression in these cells. Indeed, a number of cis -acting RNA elements have been observed within the HPV-16 late region which may be involved in control of capsid gene expression. Mechanisms controlling HPV-16 capsid gene expression and the cellular RNA-processing factors...

...S.C. Walker; T.V. Aspinall; J.M.B. Gordon; J.M. Avis In yeast, RNase MRP (mitochondrial RNA processing), a ribonucleoprotein precursor rRNA processing enzyme, possesses one putatively catalytic RNA and ten protein subunits and is highly related to RNase P. Structural analysis of the MRP RNA...

... of post-transcriptional gene expression. 1 To whom correspondence should be addressed (email Javier.Caceres@hgu.mrc.ac.uk ). 13 1 2005 © 2005 The Biochemical Society 2005 alternative splicing pre-mRNA splicing RNA processing RS domain small nuclear ribonucleoprotein (RNP...