...Jérôme O. Rouvière; Søren Lykke-Andersen; Torben Heick Jensen Transcription establishes the universal first step of gene expression where RNA is produced by a DNA-dependent RNA polymerase. The most versatile of eukaryotic RNA polymerases, RNA polymerase II (Pol II), transcribes a broad range of DNA...

...Miriam Sansó; Robert P. Fisher CDKs (cyclin-dependent kinases) ensure directionality and fidelity of the eukaryotic cell division cycle. In a similar fashion, the transcription cycle is governed by a conserved subfamily of CDKs that phosphorylate Pol II (RNA polymerase II) and other substrates...

... compare models of 3′ end formation for different classes of RNA polymerase II transcripts and formulate/propose a model of Integrator function in snRNA biogenesis. The identification of the Integrator complex will probably regenerate interest in the mechanism of snRNA 3′-end formation...

...Laura M. Elsby; Stefan G.E. Roberts Transcription by RNA polymerase II requires the assembly of the general transcription factors at the promoter to form a pre-initiation complex. The general transcription factor TF (transcription factor) IIB plays a central role in the assembly of the pre...

... (Sussex, U.K.) and Alison Tyson-Capper (Newcastle, U.K.). AR androgen receptor ERα oestrogen receptor α PCa prostate cancer P-TEFb positive transcription elongation factor b RNAPII RNA polymerase II SS splice site androgen receptor p68 DEAD box RNA...

...Sylvain Egloff; Shona Murphy Pol II (RNA polymerase II) transcribes the genes encoding proteins and non-coding snRNAs (small nuclear RNAs). The largest subunit of Pol II contains a distinctive CTD (C-terminal domain) comprising a repetitive heptad amino acid sequence, Tyr 1 -Ser 2 -Pro 3 -Thr 4...

...T. Juven-Gershon; J.-Y. Hsu; J.T. Kadonaga The RNA polymerase II core promoter is a critical yet often overlooked component in the transcription process. The core promoter is defined as the stretch of DNA, which encompasses the RNA start site and is typically approx. 40–50 nt in length...

...W. Deng; S.G.E. Roberts The general transcription factor TFIIB (transcription factor IIB) plays a critical role in the assembly of the RNA polymerase II pre-initiation complex. TFIIB can make sequence-specific DNA contacts both upstream and downstream of the TATA box. This has led to the definition...

...L.M. Elsby; S.G.E. Roberts Transcription by RNA polymerase II requires the assembly of the general transcription factors at the promoter to form a preinitiaiton complex. TFIIB (transcription factor IIB) plays a central role in this process, mediating the recruitment of RNA polymerase II...