... by which cells can generate subcellular microenvironments with specialized gene expression profiles. Particularly intriguing are recent findings that phase separation plays a role in certain RNA localization pathways. The burgeoning field of phase separation has revolutionized how we view cellular...

... change. local translation neuron RNA localization single-molecule Neurons are uniquely specialized cells, both morphologically and functionally. The elaborate arborisations of axons and dendrites overwhelmingly dominate a neuron's volume, and they can project relatively long distances away...

... disordered proteins protein turnover RNA localization Understanding how proteins, which are polymers of amino acids, carry out different functions in a cell has been a problem of considerable interest. In a series of elegant publications, Christian Anfinsen and colleagues proposed that the sequence...

... of gene expression in the testis yields information regarding both temporal and cell-type-specific regulation of transcription. As cells in the testis are large, transcripts with specific subcellular RNA localizations are readily identified. The primary spermatocyte period is characterized by high...