... is mainly found in intronic regions [ 3 ]. Therefore, it has been suggested that RNA editing predominantly occurs before splicing. In addition, ADAR2 edits its own transcript to introduce a new 3′ splice site, which in turn results in truncation of ADAR2 translation [ 1 ]. Recent deep-sequencing...

... Biochemical Society 2014 DNA-binding protein Drosophila evolution of DNA innate immunity RNA editing RNA modification History does not repeat itself, but it rhymes. Mark Twain Most of the difficulty in explaining how the RNA–DNA genome transition came about is that the current...

...Chammiran Daniel; Marie Öhman A-to-I (adenosine-to-inosine) RNA editing catalysed by the ADARs (adenosine deaminases that act on RNA) is a post-transcriptional event that contributes to protein diversity in metazoans. In mammalian neuronal ion channels, editing alters functionally important amino...