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Keywords: RAN translation
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Biochem Soc Trans (2022) 50 (1): 119–134.
Published: 23 December 2021
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 liquid-liquid phase separation neurodegeneration RAN translation repeat expansion diseases The human genome contains many simple sequence repeats composed of a short repeat unit known as a short tandem...
Biochem Soc Trans (2021) 49 (2): 775–792.
Published: 17 March 2021
...Lydia M. Castelli; Wan-Ping Huang; Ya-Hui Lin; Kung-Yao Chang; Guillaume M. Hautbergue Repeat-associated non-AUG (RAN) translation was discovered in 2011 in spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1). This non-canonical form of translation occurs in all reading frames...