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Keywords: Plasmodium falciparum
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Articles
Biochem Soc Trans (2022) 50 (3): 1069–1079.
Published: 27 May 2022
... of functionally related genes including 83 Plasmodium falciparum putatively exported proteins [ 6 ] and 73 predicted Plasmodium berghei kinases [ 7 ]. However, in order to systematically study gene function at a genome-scale, one has to move beyond the paradigm of knocking out one gene at a time. In 2016...
Articles
Biochem Soc Trans (2015) 43 (6): 1157–1163.
Published: 27 November 2015
... simulate effects of drug-induced inhibition of reaction steps on the whole-body physiology. We illustrate the approach for glucose metabolism in malaria patients, by merging two detailed kinetic models for glucose metabolism in the parasite Plasmodium falciparum and the human red blood cell with a coarse...
Articles
Biochem Soc Trans (2015) 43 (2): 240–245.
Published: 07 April 2015
..., activity and membrane binding. Proteome-scale discovery on Plasmodium falciparum schizonts has revealed a complement of more than 400 palmitoylated proteins, including those essential for host invasion and drug resistance. The wide regulatory affect on this species is endorsed by the presence of 12...
Articles
Biochem Soc Trans (2014) 42 (6): 1734–1739.
Published: 17 November 2014
... within trypanosomatid mitochondria. 1 email m.ginger@lancaster.ac.uk 5 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 enolase glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Plasmodium falciparum Trichomonas vaginalis Trypanosoma brucei...
Articles
Biochem Soc Trans (2010) 38 (5): 1337–1341.
Published: 24 September 2010
... erythrocyte Plasmodium falciparum pregnancy-associated malaria VAR2CSA Malaria is one of the most devastating infectious diseases to affect humanity, causing more than one million deaths and 500 million serious cases each year [ 1 ]. The most deadly forms of malaria are caused by the parasite...
Articles
Biochem Soc Trans (2010) 38 (3): 775–782.
Published: 24 May 2010
... ]. As such, the advent of protein import complexes in the plastid is considered to be one of the rate-limiting steps in the process of endosymbiosis [ 23 ]. apicoplast endosymbiosis malaria Plasmodium falciparum plastid P. falciparum is the intracellular obligate parasite that causes the most...
Articles
Biochem Soc Trans (2008) 36 (2): 221–228.
Published: 20 March 2008
...Srabasti J. Chakravorty; Katie R. Hughes; Alister G. Craig Cytoadherence of PRBCs ( Plasmodium falciparum -infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive...
Articles
Biochem Soc Trans (2005) 33 (5): 977–980.
Published: 26 October 2005
...S. Günther; P.J. McMillan; L.J.M. Wallace; S. Müller The human malaria parasite Plasmodium falciparum possesses a single mitochondrion and a plastid-like organelle called the apicoplast. Both organelles contain members of the KADH (α-keto acid dehydrogenase) complexes – multienzyme complexes...