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Keywords: PTEN (phosphatase and tensin homologue deleted on chromosome 10)
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Articles
Biochem Soc Trans (2004) 32 (2): 355–359.
Published: 01 April 2004
... PTEN (phosphatase and tensin homologue deleted on chromosome 10) correlates with increased invasive cell growth due to the resulting chronic activation of the PI 3-kinase (phosphoinositide 3-kinase) pathway. Induced activation of PI 3-kinase either by inhibiting PTEN expression or by using p110...
Articles
Biochem Soc Trans (2004) 32 (2): 338–342.
Published: 01 April 2004
...C.P. Downes; S. Walker; G. McConnachie; Y. Lindsay; I.H. Batty; N.R. Leslie PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a member of the protein tyrosine phosphatase family that is structurally adapted to facilitate the metabolism of 3-phosphoinositide lipid second messengers...
Articles
Biochem Soc Trans (2004) 32 (2): 348–349.
Published: 01 April 2004
... and the phosphatidylinositol 3-phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10). Specific inhibitors targeting phosphoinositide 3-kinase and protein phosphatases have been described and characterized, but no small-molecule tools for phosphoinositide phosphatases are currently available. The present...