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Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 151–165.
Published: 11 January 2021
... the essential Zinc ion in the PLpro finger domain, thus acting as a Zinc chelator [ 65 ]. Disulfiram is an aldehyde dehydrogenase inhibitor used to treat alcohol use disorder [ 66 ], and is clinically safe for extensive use. Additionally, studies have shown that Disulfiram can inhibit SARS-CoV-2 3CL pro [ 15...