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Keywords: PIK3CA
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Biochem Soc Trans (2020) 48 (1): 301–315.
Published: 03 February 2020
... in pluripotent stem cells (PSCs) and the emerging parallels to dedifferentiated cancer cells with stem cell-like features. Compelling evidence suggests that PI3K/AKT signalling forms part of a ‘core molecular stemness programme’ in both mouse and human PSCs. In cancer, the oncogenic PIK3CA H1047R variant causes...