...@biochem.dundee.ac.uk ) 11 3 2002 © 2002 Biochemical Society 2002 AKT CKI dual-specificity tyrosine-phosphorylated and -regulated kinase (DYRK) forkhead nuclear exclusion PI 3-kinase, phosphoinositide 3-kinase PKB, protein kinase B PDKI, 3-phosphoinositide-dependent kinase-1 GSK3...

... transduction tyrosine phosphorylation BCR, B-cell antigen receptor Ca 2+ , intracellular calcium CD19 −/− mice, CD19-deficient mice CD19TG mice, transgenic mice with overexpression of CD19 PI 3-kinase, phosphoinositide 3-kinase PTK, protein tyrosine kinase SHPI, SH2 domain-containing...

... receptor Btk, Bruton's tyrosine kinase PI 3-kinase, phosphoinositide 3-kinase PLC-γ2, phospholipase Cγ2 T-D, thymus-dependent TI-2, type-2 thymusindependent Biochemical Society Transactions (2002) Volume 30, part 4 B-cell development and antigen receptor signalling M. Turner' Laboratory...

... phosphoinositide PPARγ agonist Ins(1,3,4,5)P 4 , inositol 1,3,4,5-tetrakisphosphate IRS-2, insulin receptor substrate 2 PI 3-kinase, phosphoinositide 3-kinase PKB, protein kinase B PPAR, peroxisome proliferator activated receptor PtdCho, phosphatidylcholine Ptdlns(3,4,5)P 3 , phosphatidylinositol...

... and g hosphoinositides-1 GFP, green fluorescent protein GrP I, general receptor for phosphoinositides-I PH, pleckstrin homology PHISH, 3′- ph osphoinositide- i nteracting S rc- h omology-containing protein PI 3-kinase, phosphoinositide 3-kinase PLC-δ 1 , phospholipase C-δ 1 PKB, protein kinase...

...-activated protein kinase; PI 3-kinase, phosphoinositide 3-kinase. 'To whom correspondence should be addressed (e-mail lisanti@aecom.yu.edu). and its direct interaction with cholesterol [8] and probably glycosphingolipids [9], this protein is able to act as the driving force for caveolae formation [6,7...

... cells, embryonic stem cells; GSK3, glycogen synthase kinase 3; IGF. insulin-like growth factor; MSKI. mitogen- and stress-activated protein kinase I ; PDK I, 3-phosphoinositide-dependent protein kinase I ; PH, pleckstrin homology; PIF, PDK I -interacting fragment: PI 3-kinase, phosphoinositide 3-kinase...

... to be elucidated, at least some of the components in- Abbreviations used: GFP, green fluorescent protein; GSV, GLUT4 storage vesicle; NSF, N-ethylmaleimide-sensitive factor; PDK. phosphoinositide-dependent kinase; PI 3-kinase, phosphoinositide 3-kinase; PKB, protein kinase B; PKC. protein kinase C; SNAP, soluble...

... GEF, guanine-nucleotide-exchange factor GFP, green fluorescent protein GRP, general receptor for phosphoinositides PI 3-kinase, phosphoinositide 3-kinase PH, pleckstrin homology PLD, phospholipase D PORI, partner of Rac I Phospholipids: Regulators of Membrane Traffic and Signalling 26 27 28...

...M. A. Lemmon 10 3 1999 © 1999 Biochemical Society 1999 PH, pleckstrin homology; PKB, protein kinase B βARK, β-adrenergic receptor kinase Btk, Barton's tyrosine kinase PLC, phospholipase C PI 3-kinase, phosphoinositide 3-kinase Grp1, general receptor for phosphoinositides I...

...M. J. Clague; A. T. Jones; I. G. Mills; D. M. Walker; S. Urbé 8 3 1999 © 1999 Biochemical Society 1999 PI 3-kinase, phosphoinositide 3-kinase EEAI, early endosomal antigen I NSF, soluble N-ethylmaleimide-sensitive factor SNAP, soluble NSF attachment protein SNARE, SNAP...

...J.-M. Gaullier; D. Gillooly; A. Simonsen; H. Stenmark 1 To whom correspondence should be addressed 8 3 1999 © 1999 Biochemical Society 1999 PI 3-kinase, phosphoinositide 3-kinase GEF, GDP/GTP exchange factor EEAI, early-endosomal autoantigen I MVB, multivesicular body...

... products, such as PtdlnsP3. can Abbreviations used: ASM. airway smooth muscle; DHS. donor horse serum; DMC Dulbecco's Modified Eagle's medium; FCS. foetal calf serum; HRP, horse-radish pcroxidase; MAPK. mitogcn activated p a i n kinase; MEK-1, MAPK kinase; PI 3- kinase. phosphoinositide 3-kinase; PKC...

...C. A. Mitchell; S. Brown; J. K. Campbell; A. D. Munday; C. J. Speed * To whom correspondence should be addressed. 28 5 1996 © 1996 Biochemical Society 1996 5-phosphatase, inositol polyphosphate 5-phosphatase PI 3-kinase, phosphoinositide 3-kinase SH2, Src homology 2 SH3...

...A. L. Drayer; X. Pesesse; F. De Smedt; D. Communi; C. Moreau; C. Erneux 30 5 1996 © 1996 Biochemical Society 1996 OCRL, protein deficient in Lowe's oculocerebrorenal syndrome PI 3-kinase, phosphoinositide 3-kinase SH domain, Src homology domain SHIP, SH2-containing inositol...

... , PtdIns3 P , PtdIns(4,5) P 2 , PtdIns(3,4) P 2 and PtdIns(3,4,5) P 3 are phosphatidylinositol and its 4-mono, 3-mono, 4,5-bis, 3,4-bis, and 3,4,5-trisphosphate derivatives respectively PI 3-kinase, phosphoinositide 3-kinase IGF-1, insulinlike growth factor 1 NGF, nerve growth factor PDGF, platelet...