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Keywords: PARP inhibitor
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Biochem Soc Trans (2020) 48 (3): 1101–1108.
Published: 07 May 2020
.... The primary function of PARPs is to detect single-strand break (SSB), recruit DNA repair complexes, and stabilize replication forks. Homologous recombination repair (HR) is the leading high-fidelity DNA repair pathway for double-strand breaks (DSBs). The rationale of the anti-tumor effects of PARP inhibitors...