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Biochem Soc Trans (2020) 48 (3): 765–773.
Published: 05 May 2020
... induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokines from primary senescent cells. More recently, juxtacrine Notch signalling has been implicated in mediating secondary senescence induction. Primary and secondary senescent induction results in distinct...
Biochem Soc Trans (2014) 42 (6): 1563–1568.
Published: 17 November 2014
...Thaned Kangsamaksin; Ian W. Tattersall; Jan Kitajewski The Notch signalling pathway is a key regulator of developmental and tumour angiogenesis. Inhibition of Delta-like 4 (Dll4)-mediated Notch signalling results in hyper-sprouting, demonstrating that Notch regulates tip-stalk cell identity...
Biochem Soc Trans (2011) 39 (6): 1644–1648.
Published: 21 November 2011
... development and postnatal life. The interplay between the VEGF and Notch signalling pathway has been recently found to regulate the morphogenic events leading to the growth of new vessels by sprouting. Angiogenesis can also take place by an alternative process, i.e. intussusception or vascular splitting...
Biochem Soc Trans (2011) 39 (6): 1612–1618.
Published: 21 November 2011
...Chern Ein Oon; Adrian L. Harris Notch signalling is a key pathway controlling angiogenesis in normal tissues and tumours. This has become a major focus of development of anticancer therapy, but to develop this appropriately, we need further understanding of the mechanisms of regulation of Dll4...
Biochem Soc Trans (2011) 39 (5): 1327–1333.
Published: 21 September 2011
.... Protein–protein interfaces are widely recognized to be challenging targets as they tend to be large and relatively flat, and therefore usually do not have the concave binding sites that characterize the so-called ‘druggable genome’. One such prototypic multiprotein target is the Notch transcription...
Includes: Supplementary data
Biochem Soc Trans (2009) 37 (6): 1233–1236.
Published: 19 November 2009
...Lars Jakobsson; Katie Bentley; Holger Gerhardt ECs (endothelial cells) in the developing vasculature are heterogeneous in morphology, function and gene expression. Inter-endothelial signalling via Dll4 (Delta-like 4) and Notch has recently emerged as a key regulator of endothelial heterogeneity...
Biochem Soc Trans (2009) 37 (1): 137–142.
Published: 20 January 2009
... targeting them for degradation in lysosomes. In the present paper, we review how ESCRT-mediated receptor down-regulation affects signalling downstream of Notch and growth factor receptors, and how ESCRTs may control cell proliferation, survival and cytoskeletal functions and contribute to tumour suppression...
H.B. Osborne, C. Gautier-Courteille, A. Graindorge, C. Barreau, Y. Audic, R. Thuret, N. Pollet, L. Paillard
Biochem Soc Trans (2005) 33 (6): 1541–1543.
Published: 26 October 2005
... in Drosophila oocytes. Recent data showed that this regulatory process is required for somitic segmentation in Xenopus . Inactivation of EDEN-BP (EDEN-binding protein) causes severe segmentation defects, and the expression of segmentation markers in the Notch signalling pathway is disrupted. We showed...