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Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 72–77.
Published: 19 January 2010
... A and Nek2A, are normally degraded at nuclear-envelope breakdown, even when the spindle checkpoint is active. This indicates that the APC/C is activated early in mitosis, whereas cyclin B1 and securin are protected as long as the spindle checkpoint inhibits Cdc20. Remarkably, destruction of cyclin A and Nek2A...