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Keywords: NOTUM
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1797–1808.
Published: 09 December 2022
... in maintaining proper structure and activities. Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins. Additionally, NOTUM is a secreted extracellular...
