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Keywords: NMR
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Articles
Biochem Soc Trans (2019) 47 (1): 63–76.
Published: 21 December 2018
... of methods to reveal artifacts and, in general, for understanding more thoroughly the nature of a validation process. The concept of the validation cross was originally introduced for the validation of protein–ligand interactions by NMR in drug discovery. Here, an attempt is made to expand the concept...
Articles
Biochem Soc Trans (2014) 42 (1): 52–58.
Published: 23 January 2014
... GTPase NMR Ral Ral-binding protein 1 (RalBP1) Ral-interacting protein of 76 kDa (RLIP76) structural biology Small GTPases of the Ras superfamily are characterized by their ability to switch between the GDP-bound ‘off’ state and the GTP-bound active state in response to upstream signals...
Articles
Biochem Soc Trans (2014) 42 (1): 139–144.
Published: 23 January 2014
... of York, U.K., 17–19 June 2013. Organized and Edited by Nicholas Brindle (University of Leicester, U.K.), Sandip Patel (University College London, U.K.) and Stephen Yarwood (University of Glasgow, U.K.) allostery cAMP cGMP covariance NMR protein dynamics singular value decomposition (SVD...
Articles
Biochem Soc Trans (2012) 40 (2): 424–428.
Published: 21 March 2012
...Angelo Miguel Figueiredo; Geoffrey R. Moore; Sara B.-M. Whittaker Understanding the mechanism of folding of small proteins requires characterization of their starting unfolded states and any partially unfolded states populated during folding. Here, we review what is known from NMR about...
Articles
Biochem Soc Trans (2012) 40 (2): 419–423.
Published: 21 March 2012
... of galectin-3). NMR relaxation experiments provide a unique probe of conformational entropy by characterizing bond-vector fluctuations at atomic resolution. By monitoring differences between the free and ligand-bound states in their backbone and side chain order parameters, we have estimated the contributions...
Articles
Biochem Soc Trans (2008) 36 (6): 1433–1437.
Published: 19 November 2008
...Nils-Alexander Lakomek; Oliver F. Lange; Korvin F.A. Walter; Christophe Farès; Dalia Egger; Peter Lunkenheimer; Jens Meiler; Helmut Grubmüller; Stefan Becker; Bert L. de Groot; Christian Griesinger RDCs (residual dipolar couplings) in NMR spectroscopy provide information about protein dynamics...
Articles
Biochem Soc Trans (2007) 35 (5): 985–990.
Published: 25 October 2007
...D.A. Middleton Structure-based design has gained credibility as a valuable component of the modern drug discovery process. The technique of SSNMR (solid-state NMR) promises to be a useful counterpart to the conventional experimental techniques of X-ray crystallography and solution-state NMR...
Articles
Biochem Soc Trans (2005) 33 (5): 913–915.
Published: 26 October 2005
..., alternating between an orientation that lies across the membrane surface and an upright orientation that associates with the regulatory site of SERCA. circular dichroism (CD) fluorescence spectroscopy membrane binding NMR phospholamban Heart muscle relaxation is triggered by the rapid...
Articles
Biochem Soc Trans (2005) 33 (4): 873–877.
Published: 01 August 2005
..., the emerging technique, solid-state NMR, can be used for the investigation of these transporters. A number of experiments based on MAS (magic angle sample spinning) NMR are available to provide data on protein structure and dynamics, drug binding and protein–lipid interactions. However, these experiments...
Articles
Biochem Soc Trans (2005) 33 (4): 767–771.
Published: 01 August 2005
... and rational drug design. The applications of NMR spectroscopy and isothermal titration calorimetry to study enzyme–ligand interactions will be discussed. Recent work on ketopantoate reductase, which catalyses an important step on the biosynthetic pathway to vitamin B5, is used to illustrate the potential...
Articles
Biochem Soc Trans (2005) 33 (3): 447–449.
Published: 01 June 2005
...@nmrfam.wisc.edu ). catalytic core NMR structure spliceosome U2 RNA U6 RNA There are several interesting implications of the observed four-way junction fold. First, the extended U6 ISL in this structure closely resembles domain 5, the catalytic core of group II self-splicing introns, particularly...
Articles
Biochem Soc Trans (2004) 32 (5): 721–723.
Published: 26 October 2004
... binding lipoprotein NMR structure The LDLR (low-density lipoprotein receptor) mediates cellular uptake of cholesterol-laden lipoprotein particles from the circulation. The receptor binds cholesterol-carrying LDL particles at the cell surface at neutral pH, transporting them to endosomes where...
Articles
Biochem Soc Trans (2004) 32 (6): 1127–1129.
Published: 26 October 2004
... hydrophobic region of α-synuclein comprising residues 71–82 is required for aggregation of the protein into the fibrillar form found in pathogenic aggregates [Giasson, Murray, Trojanowski and Lee (2001) J. Biol. Chem. 276 , 2380–2386]. In the present study, we used 2 H NMR and electron microscopy...
Articles
Biochem Soc Trans (2004) 32 (1): 28–32.
Published: 01 February 2004
... Cascades, a Biochemical Society Focused Meeting held at GlaxoSmithKline, Stevenage, 9 September 2003 12 August 2003 © 2004 Biochemical Society 2004 complement system compstatin drug design molecular dynamics NMR peptide Abbreviations used: Ac, acetyl; MD, molecular...
Articles
Biochem Soc Trans (2002) 30 (6): 990–996.
Published: 01 November 2002
...-mail Paul.Barlowa@ac.uk ) 18 6 2002 © 2002 Biochemical Society 2002 complement module multiple domain NMR X-ray crystallography CCP, complement control protein module CR, complement receptor: HSQC, heteronuclear single-quantum coherence: LHR, long homologous repeat: MCP, membrane...
Articles
Biochem Soc Trans (2002) 30 (6): 1026–1036.
Published: 01 November 2002
... be addressed (e-mail dmorikis@engr.ucr.edu or lambris@mail.med.upenn.edu ) 21 6 2002 © 2002 Biochemical Society 2002 complement system drug design NMR Ac, acetyl group C5aR, C5a receptor dCha, D-cyclohexylalanine dX, D-isomer of amino acid X Nme, N-methylamide Biochemical...
Articles
Biochem Soc Trans (2002) 30 (6): 919–924.
Published: 01 November 2002
...D. Pantoja-Uceda; M. Bruix; J. Santoro; M. Rico; R. Monsalve; M. Villalba The NMR solution structures at different levels of refinement of three different 2 S albumin seed proteins, the recombinant pronapin precursor from Brassica napus , the recombinant RicC3 from Ricinus communis...
Articles
Biochem Soc Trans (2002) 30 (4): 521–525.
Published: 01 August 2002
... elucidation is impeded by fibril insolubility and inability to crystallize, thus preventing the use of X-ray crystallography and solution NMR. CD, Fourier-transform infrared spectroscopy and light scattering have been used in the study of the mechanism of fibril formation. This review concentrates...