... permeability. The mechanistic role of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase)-induced oxidative stress in these events will also be addressed. 1 To whom correspondence should be addressed (email phil.cummins@dcu.ie ) . 16 12 2014 © 2015 Authors; published...

... was dependent on the higher cholesterol level in the membrane of astrocytes compared with neurons. The Aβ-induced calcium signal stimulated NADPH oxidase and induced increased reactive oxygen species (ROS) production. These events are detectable at physiologically relevant concentrations of Aβ. Excessive ROS...

... Biochemical Society 2010 exocyst NADPH oxidase phospholipase D Rab Rop small GTPase Plant cell morphogenesis relies upon a dynamic network of processes integrating cell wall dynamics with signal transduction, changes in ion membrane transports, membrane lipid modifications, regulation...

... of NADPH oxidases. Several NOX isoforms are expressed in the liver and pancreatic β-cells. There is now evidence that inappropriate activation of NOX enzymes may damage the liver and pancreatic β-cells. In the context of the metabolic syndrome, the emerging epidemic of non-alcoholic steatohepatitis...

... Biochemical Society 2007 ATP ion channel NADPH oxidase P2X 7 phosphoinositide 3-kinase (PI3K) reactive nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic...

... 2007 dopaminergic neuron microglia NADPH oxidase neuroinflammation Parkinson's disease reactive oxygen species Microglia, the resident innate immune cells in the brain, are activated in response to neuronal damage and several environmental stimuli/toxins. While most of the microglial...

...P. Behe; A.W. Segal The NADPH oxidase of ‘professional’ phagocytic cells transfers electrons across the wall of the phagocytic vacuole, forming superoxide in the lumen. It is generally accepted that this system promotes microbial killing through the generation of reactive oxygen species and through...

..., ROS (reactive oxygen species) also have signalling roles, acting as second messengers that modulate the activity of diverse intracellular signalling pathways and transcription factors, thereby inducing changes in cell phenotype. NADPH oxidases appear to be especially important sources of ROS involved...

... specialized functions distinct from superoxide dismutation. 1 e-mail andrea.battistoni@uniroma2.it 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 1 July 2003 © 2003 Biochemical Society 2003 NADPH oxidase respiratory burst...

... Society 2001 gene expression hydrogen peroxide MAP kinases NADPH oxidase signal transduction MAP kinase, mitogen-activated protein kinase NF-κB, nuclear factor-κB NOH, NADPH oxidase homologue ROS, reactive oxygen species SOD, superoxide dismutase Biochemical and Biomedical Aspects...