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Keywords: NADPH oxidase
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Articles
Biochem Soc Trans (2015) 43 (4): 702–706.
Published: 03 August 2015
... permeability. The mechanistic role of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase)-induced oxidative stress in these events will also be addressed. 1 To whom correspondence should be addressed (email phil.cummins@dcu.ie ) . 16 12 2014 © 2015 Authors; published...
Articles
Biochem Soc Trans (2014) 42 (5): 1286–1290.
Published: 18 September 2014
... was dependent on the higher cholesterol level in the membrane of astrocytes compared with neurons. The Aβ-induced calcium signal stimulated NADPH oxidase and induced increased reactive oxygen species (ROS) production. These events are detectable at physiologically relevant concentrations of Aβ. Excessive ROS...
Articles
Biochem Soc Trans (2010) 38 (2): 723–728.
Published: 22 March 2010
... (e.g. membrane lipid-modifying enzymes and NADPH oxidases). We focus here exclusively on the plant effectors of Rab and Rop GTPases as their regulators have been described in detail previously [ 2 – 5 ]. Non-covalent binding of GTP to small GTPase proteins imposes conformational changes...
Articles
Biochem Soc Trans (2008) 36 (5): 920–929.
Published: 19 September 2008
... of NADPH oxidases. Several NOX isoforms are expressed in the liver and pancreatic β-cells. There is now evidence that inappropriate activation of NOX enzymes may damage the liver and pancreatic β-cells. In the context of the metabolic syndrome, the emerging epidemic of non-alcoholic steatohepatitis...
Articles
Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... compelling evidence for the contribution of P2X 7 Rs in ATP-mediated changes in cellular oxidation. Significant cellular sources of O 2 − generation, and ultimately the generation of other RONS (e.g. H 2 O 2 , hydroxyl radical and peroxynitrite), include NADPH oxidase, xanthine oxidoreductase...
Articles
Biochem Soc Trans (2007) 35 (5): 1100–1103.
Published: 25 October 2007
...P. Behe; A.W. Segal The NADPH oxidase of ‘professional’ phagocytic cells transfers electrons across the wall of the phagocytic vacuole, forming superoxide in the lumen. It is generally accepted that this system promotes microbial killing through the generation of reactive oxygen species and through...
Articles
Biochem Soc Trans (2007) 35 (5): 1127–1132.
Published: 25 October 2007
... 2007 dopaminergic neuron microglia NADPH oxidase neuroinflammation Parkinson's disease reactive oxygen species Microglia, the resident innate immune cells in the brain, are activated in response to neuronal damage and several environmental stimuli/toxins. While most of the microglial...
Articles
Biochem Soc Trans (2006) 34 (5): 960–964.
Published: 25 October 2006
..., ROS (reactive oxygen species) also have signalling roles, acting as second messengers that modulate the activity of diverse intracellular signalling pathways and transcription factors, thereby inducing changes in cell phenotype. NADPH oxidases appear to be especially important sources of ROS involved...
Articles
Biochem Soc Trans (2003) 31 (6): 1326–1329.
Published: 01 December 2003
... specialized functions distinct from superoxide dismutation. 1 e-mail andrea.battistoni@uniroma2.it 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 1 July 2003 © 2003 Biochemical Society 2003 NADPH oxidase respiratory burst...
Articles
Biochem Soc Trans (2001) 29 (2): 345–349.
Published: 01 May 2001
... Society 2001 gene expression hydrogen peroxide MAP kinases NADPH oxidase signal transduction MAP kinase, mitogen-activated protein kinase NF-κB, nuclear factor-κB NOH, NADPH oxidase homologue ROS, reactive oxygen species SOD, superoxide dismutase Biochemical and Biomedical Aspects...