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Keywords: NAD+
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Biochem Soc Trans (2004) 32 (6): 904–909.
Published: 26 October 2004
...R. Marmorstein The yeast Sir2 (silent information regulator-2) protein functions as an NAD + -dependent histone deacetylase to silence gene expression from the mating-type locus, tolomeres and rDNA and also promotes longevity and genome stability in response to calorie restriction. Homologues...