...Anthony J. Morgan; Lora L. Martucci; Lianne C. Davis; Antony Galione In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P 2 , TPCs are an integral part...

... ) and IP 3 receptor (IP 3 R) on the endoplasmic reticulum (ER). A less understood, parallel Ca 2+ signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca 2+ release from acidic Ca 2+ stores [e.g. endo-lysosomes, secretory vesicles...

...Anthony J. Morgan; Lianne C. Davis; Margarida Ruas; Antony Galione The Ca 2+ -mobilizing second messenger, NAADP (nicotinic acid adenine dinucleotide phosphate), has been with us for nearly 20 years and yet we still cannot fully agree on the identity of its target Ca 2+ -release channel. In spite...

...Jonathan S. Marchant; Sandip Patel Two-pore channels (TPCs) are ancient members of the voltage-gated ion channel superfamily that localize to acidic organelles such as lysosomes. The TPC complex is the proposed target of the Ca 2+ -mobilizing messenger NAADP, which releases Ca 2+ from these acidic...

...J. Gerasimenko; Y. Maruyama; A. Tepikin; O.H. Petersen; O. Gerasimenko We have compared calcium mobilization by Ins(1,4,5) P 3 (IP 3 ), cADP-ribose (cADPR) and nicotinic acid–adenosine dinucleotide phosphate (NAADP) from the envelope of isolated nuclei with the calcium signalling in intact isolated...