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Keywords: Mycobacterium tuberculosis
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Articles
Biochem Soc Trans (2020) 48 (5): 2029–2037.
Published: 11 September 2020
...J. Shaun Lott Mycobacterium tuberculosis , the causative agent of tuberculosis (TB), is the most significant cause of death from a single infectious agent worldwide. Antibiotic-resistant strains of M. tuberculosis represent a threat to effective treatment, and the long duration, toxicity...
Articles
Biochem Soc Trans (2019) 47 (4): 1091–1099.
Published: 27 June 2019
...@ucl.ac.uk ) 5 3 2019 10 5 2019 28 5 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 expression platform Gram-negative bacteria Gram-positive bacteria Mycobacterium tuberculosis riboswitches termination...
Articles
Biochem Soc Trans (2019) 47 (3): 847–860.
Published: 13 May 2019
...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Correspondence: Christina Julius ( C.Julius2@ncl.ac.uk ) antimicrobials bacteriophages Mycobacterium tuberculosis RNA polymerase transcription Treatment of drug-susceptible (DS)-TB is successful in 86...
Articles
Biochem Soc Trans (2016) 44 (1): 68–73.
Published: 09 February 2016
...Stephen Bornemann It has long been reported that Mycobacterium tuberculosis is capable of synthesizing the α-glucan glycogen. However, what makes this bacterium stand out is that it coats itself in a capsule that mainly consists of a glycogen-like α-glucan. This polymer helps the pathogen evade...
Articles
Biochem Soc Trans (2012) 40 (3): 573–579.
Published: 22 May 2012
.... In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns...
Articles
Biochem Soc Trans (2010) 38 (5): 1286–1289.
Published: 24 September 2010
...Dany J.V. Beste; Johnjoe McFadden Despite decades of research, many aspects of the biology of Mycobacterium tuberculosis remain unclear, and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem...
Articles
Biochem Soc Trans (2009) 37 (2): 333–335.
Published: 20 March 2009
... 2009 enzymology hydrogen tunnelling kinetics Mycobacterium tuberculosis nitric oxide synthase (NOS) quantum mechanics/molecular mechanics (QM/MM) Was there ever a time when enzymology and its development were so important to the progression of the biological sciences? With an explosion...
Articles
Biochem Soc Trans (2008) 36 (4): 555–565.
Published: 22 July 2008
... To whom correspondence should be addressed (email g.besra@bham.ac.uk ). 9 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 arabinogalactan biosynthesis cell wall drug target Mycobacterium tuberculosis mycolic acid Despite the development...
Articles
Biochem Soc Trans (2007) 35 (5): 1325–1328.
Published: 25 October 2007
... lipoarabinomannan Mycobacterium tuberculosis The Mycobacterium tuberculosis cell envelope differs substantially from the cell wall structures of both Gram-negative and Gram-positive bacteria. This unique cell wall structure accounts for its unusual low permeability and resistance towards common...
Articles
Biochem Soc Trans (2006) 34 (6): 1178–1182.
Published: 25 October 2006
...K.J. McLean; A.J. Dunford; M. Sabri; R. Neeli; H.M. Girvan; P.R. Balding; D. Leys; H.E. Seward; K.R. Marshall; A.W. Munro An extraordinary array of P450 (cytochrome P450) enzymes are encoded on the genome of the human pathogen Mycobacterium tuberculosis (Mtb) and in related mycobacteria...
Articles
Biochem Soc Trans (2005) 33 (4): 802–805.
Published: 01 August 2005
... and MS. Because Mycobacterium tuberculosis DAPA AT is a potential drug target, this enzyme was cloned, overexpressed and purified to homogeneity for biochemical characterization. 1 Correspondence may be addressed to either of the authors (email mann@ccr.jussieu.fr or ploux@ccr.jussieu.fr...
Articles
Biochem Soc Trans (2003) 31 (3): 520–522.
Published: 01 June 2003
... representative chromosomally encoded aminoglycoside N-acetyltransferases, Mycobacterium tuberculosis AAC(2´)-Ic and Salmonella enterica AAC(6´)-Iy, and speculate about their possible physiological function and substrates. 1 To whom correspondence should be addressed (e-mail blanchar@aecom.yu.edu...