... chain membrane proteins Mycobacterium tuberculosis protein structure Bacteria of the genus Mycobacterium include pathogenic species such as M. tuberculosis , M. leprae , M. avium , M. abscessus (sometimes called Mycobacteroides abscessus ), and M. ulcerans, as well as non-pathogenic...

...J. Shaun Lott Mycobacterium tuberculosis , the causative agent of tuberculosis (TB), is the most significant cause of death from a single infectious agent worldwide. Antibiotic-resistant strains of M. tuberculosis represent a threat to effective treatment, and the long duration, toxicity...

...@ucl.ac.uk ) 5 3 2019 10 5 2019 28 5 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 expression platform Gram-negative bacteria Gram-positive bacteria Mycobacterium tuberculosis riboswitches termination...

...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 antimicrobials bacteriophages Mycobacterium tuberculosis RNA polymerase transcription The current first-line treatment of drug-sensitive TB (DS-TB) involves a 6-month course of rifampicin (inhibition of bacterial...

...Stephen Bornemann It has long been reported that Mycobacterium tuberculosis is capable of synthesizing the α-glucan glycogen. However, what makes this bacterium stand out is that it coats itself in a capsule that mainly consists of a glycogen-like α-glucan. This polymer helps the pathogen evade...

.... In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns...

...Dany J.V. Beste; Johnjoe McFadden Despite decades of research, many aspects of the biology of Mycobacterium tuberculosis remain unclear, and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem...

... 2009 enzymology hydrogen tunnelling kinetics Mycobacterium tuberculosis nitric oxide synthase (NOS) quantum mechanics/molecular mechanics (QM/MM) Was there ever a time when enzymology and its development were so important to the progression of the biological sciences? With an explosion...

... Mycobacterium tuberculosis mycolic acid Figure 2 Schematic representation of the lipoarabinomannan (LAM) biosynthesis pathway in mycobacteria GT-C, glycosyltransferase family C enzyme; PI, phosphatidylinositol; PP, polyprenyl phosphate. Recent studies have elucidated a number of the key...

.... Vissa V.D. Chatterjee D. Brennan P.J. Crick D.C. J. Biol. Chem. 2006 281 20027 20035 1 To whom correspondence should be addressed (email g.besra@bham.ac.uk ). 8 6 2007 arabinogalactan cell wall drug target lipoarabinomannan Mycobacterium tuberculosis...

...K.J. McLean; A.J. Dunford; M. Sabri; R. Neeli; H.M. Girvan; P.R. Balding; D. Leys; H.E. Seward; K.R. Marshall; A.W. Munro An extraordinary array of P450 (cytochrome P450) enzymes are encoded on the genome of the human pathogen Mycobacterium tuberculosis (Mtb) and in related mycobacteria...

... and MS. Because Mycobacterium tuberculosis DAPA AT is a potential drug target, this enzyme was cloned, overexpressed and purified to homogeneity for biochemical characterization. Inactivation of Escherichia coli DAPA AT by amiclenomycin and analogues was carefully studied using different approaches...

... representative chromosomally encoded aminoglycoside N-acetyltransferases, Mycobacterium tuberculosis AAC(2´)-Ic and Salmonella enterica AAC(6´)-Iy, and speculate about their possible physiological function and substrates. 1 To whom correspondence should be addressed (e-mail blanchar@aecom.yu.edu...