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Keywords: Kelch-like ECH-associated protein 1 (Keap1)
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Articles
Biochem Soc Trans (2015) 43 (4): 639–644.
Published: 03 August 2015
... electrophilic or oxidative stressors. Kelch-like ECH-associated protein 1 (Keap1) binds Nrf2 in the cytoplasm and facilitates its proteasomal degradation. Keap1 possesses a series of reactive cysteines that can be modified by exposure to oxidants and electrophiles. This modification induces allosteric changes...
Articles
Biochem Soc Trans (2015) 43 (4): 621–626.
Published: 03 August 2015
... phosphate pathway [ 7 ]. Cellular levels of Nrf2 are strictly regulated by multiple mechanisms, not all of which are fully defined. The best characterized mechanism of Nrf2 regulation is mediated by interaction with the Kelch-like ECH-associated protein 1 (Keap1)–Cullin3–Rbx1 complex, which mediates Nrf2...
Articles
Biochem Soc Trans (2015) 43 (4): 645–649.
Published: 03 August 2015
...Hanna M. Leinonen; Emilia Kansanen; Petri Pölönen; Merja Heinäniemi; Anna-Liisa Levonen Accumulating evidence suggests that dysregulation of the Kelch-like ECH-associated protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2) pathway resulting in constitutively active Nrf2 and increased...
Articles
Biochem Soc Trans (2015) 43 (4): 680–686.
Published: 03 August 2015
...-stress conditions, Nrf2 is under tight regulation by the ubiquitin proteasome system (UPS). Detailed mechanistic investigations have shown the Kelch-like ECH-associated protein 1 (Keap1)–cullin3 (Cul3)–ring-box1 (Rbx1) E3-ligase to be the primary Nrf2 regulatory system. Recently, both beta-transducin...
Articles
Articles
Biochem Soc Trans (2015) 43 (4): 657–662.
Published: 03 August 2015
... by Portland Press Limited 2015 antioxidant response element hazard assessment Kelch-like ECH-associated protein 1 (Keap1) nuclear factor erythroid 2-related factor 2 (Nrf2) stress response toxicity The process of evolution has enabled mammalian cells to withstand continuous exposure...
Articles
Biochem Soc Trans (2015) 43 (4): 674–679.
Published: 03 August 2015
... been proposed as a therapeutic intervention in a range of chronic neurodegenerative conditions and cancer chemoprevention. One of the main mechanisms by which Nrf2 is negatively regulated involves an interaction with the ubiquitination facilitator protein, Kelch-like ECH-associated protein 1 (Keap1...