... leiomyomatosis and renal cell cancer (HLRCC) hereditary tyrosinemia type 1 Kelch-like ECH-associated protein 1 (KEAP1) nuclear erythroid 2-like 2 transcription factor (NRF2) Carcinogen-induced tumours may also follow a similar path. The biological insights acquired from these hereditary syndromes...

... an outlook on the potential value of monitoring Nrf2 activity for improving the pre-clinical identification of chemicals and drugs with toxic liability in humans. antioxidant response element hazard assessment Kelch-like ECH-associated protein 1 (Keap1) nuclear factor erythroid 2-related factor 2 (Nrf2...

... been proposed as a therapeutic intervention in a range of chronic neurodegenerative conditions and cancer chemoprevention. One of the main mechanisms by which Nrf2 is negatively regulated involves an interaction with the ubiquitination facilitator protein, Kelch-like ECH-associated protein 1 (Keap1...

... (email dic16@pitt.edu ) . 13 2 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer Kelch-like ECH-associated protein 1 (Keap1) lipogenesis metabolism nuclear erythroid factor 2-like 2 (Nrf2) pentose phosphate pathway Nuclear erythroid factor 2-like 2...

... kinase beta (IKKβ) Kelch-like ECH-associated protein 1 (Keap1) nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear factor-κB (NF-κB) neurodegeneration Figure 2 Common interactions between p65 and Nrf2 Data obtained from BioGRID were filtered to remove those identified only by co...

...Hanna M. Leinonen; Emilia Kansanen; Petri Pölönen; Merja Heinäniemi; Anna-Liisa Levonen Accumulating evidence suggests that dysregulation of the Kelch-like ECH-associated protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2) pathway resulting in constitutively active Nrf2 and increased...

...-stress conditions, Nrf2 is under tight regulation by the ubiquitin proteasome system (UPS). Detailed mechanistic investigations have shown the Kelch-like ECH-associated protein 1 (Keap1)–cullin3 (Cul3)–ring-box1 (Rbx1) E3-ligase to be the primary Nrf2 regulatory system. Recently, both beta-transducin...