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Keywords: KRAS
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Articles
Biochem Soc Trans (2021) 49 (1): 467–476.
Published: 05 February 2021
...Rohan Chippalkatti; Daniel Abankwa Cancer stem cells (CSC) may be the most relevant and elusive cancer cell population, as they have the exquisite ability to seed new tumors. It is plausible, that highly mutated cancer genes, such as KRAS , are functionally associated with processes contributing...
Articles
Biochem Soc Trans (2020) 48 (6): 2691–2701.
Published: 26 November 2020
...Atanu Chakraborty Oncogenic mutation in KRAS is one of the most common alterations in human cancer. After decades of extensive research and unsuccessful drug discovery programs, therapeutic targeting of KRAS mutant tumour is at an exciting juncture. The discovery of mutation-specific inhibitors...
Articles
Biochem Soc Trans (2019) 47 (4): 961–972.
Published: 24 July 2019
... since the majority of patients diagnosed with PDAC present with advanced unresectable disease, which is highly resistant to all forms of chemotherapy and radiotherapy. Activating mutations of an isoform of the RAS protein, KRAS, are found in almost all PDAC cases and occur during early stages...
Articles
Biochem Soc Trans (2014) 42 (4): 742–746.
Published: 11 August 2014
... and reproduction in any medium, provided the original work is properly cited. cancer GTPase HRAS KRAS NRAS RAS proteins are membrane-bound small GTPases that act as molecular switches downstream of cell-surface receptors. Upon GTP binding, RAS changes conformation, revealing an effector-binding...