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Keywords: KRAS
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Articles
Biochem Soc Trans (2023) 51 (3): 1191–1199.
Published: 24 May 2023
...Juan Kochen Rossi; Cristina Nuevo-Tapioles; Mark R. Philips RAS proteins are small GTPases that transduce signals from membrane receptors to signaling pathways that regulate growth and differentiation. Four RAS proteins are encoded by three genes — HRAS, KRAS, NRAS. Among them, KRAS is mutated...
Articles
Biochem Soc Trans (2021) 49 (1): 467–476.
Published: 05 February 2021
...Rohan Chippalkatti; Daniel Abankwa Cancer stem cells (CSC) may be the most relevant and elusive cancer cell population, as they have the exquisite ability to seed new tumors. It is plausible, that highly mutated cancer genes, such as KRAS , are functionally associated with processes contributing...
Articles
Biochem Soc Trans (2020) 48 (6): 2691–2701.
Published: 26 November 2020
...Atanu Chakraborty Oncogenic mutation in KRAS is one of the most common alterations in human cancer. After decades of extensive research and unsuccessful drug discovery programs, therapeutic targeting of KRAS mutant tumour is at an exciting juncture. The discovery of mutation-specific inhibitors...
Articles
Biochem Soc Trans (2019) 47 (4): 961–972.
Published: 24 July 2019
... since the majority of patients diagnosed with PDAC present with advanced unresectable disease, which is highly resistant to all forms of chemotherapy and radiotherapy. Activating mutations of an isoform of the RAS protein, KRAS, are found in almost all PDAC cases and occur during early stages...
Articles
Biochem Soc Trans (2014) 42 (4): 742–746.
Published: 11 August 2014
... and reproduction in any medium, provided the original work is properly cited. cancer GTPase HRAS KRAS NRAS This illustrates the importance of studying isoform-specific function in an endogenous context, since a subset of isoform-specific differences may result from the disparity...