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Keywords: Janus kinase (JAK)
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Articles
Biochem Soc Trans (2014) 42 (1): 59–62.
Published: 23 January 2014
... (ERK) inflammation interleukin 6-type cytokine Janus kinase (JAK) signal transducer and activator of transcription (STAT) IL (interleukin)-6-type cytokines are critical molecules that determine health and disease in many living organisms (reviewed in [ 1 , 2 ]). The IL-6 family of cytokines...
Articles
Biochem Soc Trans (2013) 41 (4): 1048–1054.
Published: 18 July 2013
... (email stefan.constantinescu@bru.licr.org ). 20 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 blood cancer Janus kinase (JAK) myeloproliferative disorder pseudokinase domain The human genome codes for four JAKs (Janus kinases, although JAK...
Articles
Biochem Soc Trans (2013) 41 (4): 1002–1007.
Published: 18 July 2013
...@med.nyu.edu ). 30 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cytokine Janus kinase (JAK) pseudokinase signalling structure The JAK family of non-receptor tyrosine kinases consists of four members (JAK1–JAK3 and Tyk2) that function as triggering...
Articles
Biochem Soc Trans (2013) 41 (4): 1042–1047.
Published: 18 July 2013
... Society 2013 cytokine signalling Janus kinase (JAK) signal transducer and activator of transcription (STAT) suppressor of cytokine signalling (SOCS) Cytokines signal by binding to specific cell-surface receptors on their target cell. The cytoplasmic domains of these cytokine receptors...
Articles
Biochem Soc Trans (2012) 40 (1): 215–218.
Published: 19 January 2012
... cytokine exchange protein directly activated by cAMP (Epac) Janus kinase (JAK) signal transducer and activator of transcription (STAT) suppressor of cytokine signalling (SOCS) ubiquitin ligase Cytokines control many important biological responses, including haemopoiesis, inflammation and T...
Articles
Biochem Soc Trans (2008) 36 (3): 328–333.
Published: 21 May 2008
... diabetes interferon γ (IFNγ) Janus kinase (JAK) signal transducer and activator of transcription (STAT) Type 1 diabetes results from an autoimmune destruction of the insulin-producing β-cells of the islets of Langerhans in the pancreas. β-Cells under attack die mainly through apoptosis. One...