... (ERK) inflammation interleukin 6-type cytokine Janus kinase (JAK) signal transducer and activator of transcription (STAT) IL (interleukin)-6-type cytokines are critical molecules that determine health and disease in many living organisms (reviewed in [ 1 , 2 ]). The IL-6 family of cytokines...

... conformations for JAK3 differ from the other JAKs. JAK1 V658F was found in a fraction of acute adult T-ALL (T-lymphoblastoid leukaemia) and in several other leukaemic conditions [ 53 – 55 ]. blood cancer Janus kinase (JAK) myeloproliferative disorder pseudokinase domain The human genome codes...

... 2013 Biochemical Society 2013 cytokine Janus kinase (JAK) pseudokinase signalling structure The JAK family of non-receptor tyrosine kinases consists of four members (JAK1–JAK3 and Tyk2) that function as triggering kinases in cytokine and hormone signalling [ 1 , 2 ]. The JAKs share...

... (email babon@wehi.edu.au ). 3 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cytokine signalling Janus kinase (JAK) signal transducer and activator of transcription (STAT) suppressor of cytokine signalling (SOCS) Cytokines signal by binding...

... cytokine exchange protein directly activated by cAMP (Epac) Janus kinase (JAK) signal transducer and activator of transcription (STAT) suppressor of cytokine signalling (SOCS) ubiquitin ligase Cytokines control many important biological responses, including haemopoiesis, inflammation and T...

... destruction in Type 1 diabetes [ 51 ]. β-cell cytokine diabetes interferon γ (IFNγ) Janus kinase (JAK) signal transducer and activator of transcription (STAT) Type 1 diabetes results from an autoimmune destruction of the insulin-producing β-cells of the islets of Langerhans...