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Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 833–836.
Published: 25 October 2006
...-arrestin, MEK partner-1, Sef and IQGAP1. Scaffolds organize multiprotein signalling complexes. This targets MEK/ERK to specific substrates and facilitates communication with other pathways, thereby mediating diverse functions. The adaptor proteins regulate the kinetics, amplitude and localization of MEK...