...William J. Griffiths; Yuqin Wang In the present study, we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington's disease, Parkinson's disease...

... of sleep [ 12 – 14 ]. © The Authors Journal compilation © 2014 Biochemical Society 2014 Alzheimer’s disease amyotrophic lateral sclerosis glia Huntington’s disease neurodegeneration Parkinson’s disease Evidence favouring the involvement of early degenerative changes in astroglia...

...Edward W. Green; Flaviano Giorgini HD (Huntington's disease) is a fatal inherited gain-of-function disorder caused by a polyQ (polyglutamine) expansion in the htt (huntingtin protein). Expression of mutant htt in model organisms is sufficient to recapitulate many of the cellular defects found in HD...

...Sarah L. Hands; Robert Mason; M. Umar Sajjad; Flaviano Giorgini; Andreas Wyttenbach HD (Huntington's disease) is caused by a polyQ (polyglutamine) expansion in the huntingtin protein, which leads to protein misfolding and aggregation of this protein. Abnormal copper accumulation in the HD brain...

...Claire M. Kelly; Stephen B. Dunnett; Anne E. Rosser Cell-replacement therapy for Huntington's disease is one of very few therapies that has reported positive outcomes in clinical trials. However, for cell transplantation to be made more readily available, logistical, standardization and ethical...