... To whom correspondence should be addressed (email dalem@cmmt.ubc.ca ). 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 apoptosis autophagy caspases huntingtin Huntington disease post-translational myristoylation Since the discovery of post...

..., dementia and emotional dysfunction, eventually resulting in death. HD is caused by an expanded CAG repeat in the first exon of the HD gene that results in an abnormally elongated polyQ (polyglutamine) tract in its protein product, Htt (Huntingtin). Wild-type Htt is largely cytoplasmic; however, in HD...