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Christian A. Lobos, Jonathan Downing, Lloyd J. D'Orsogna, Demetra S.M. Chatzileontiadou, Stephanie Gras
Biochem Soc Trans (2022) 50 (5): 1329–1339.
Published: 16 September 2022
.... The discovery of the human immunodeficiency virus (HIV) virus as the causing agent of acquired immunodeficiency syndrome (AIDS) decades ago, led to a tremendous amount of research. Among the findings, it was discovered that some rare HIV + individuals, called HIV controllers (HICs), had the ability to control...
Biochem Soc Trans (2021) 49 (4): 1735–1748.
Published: 26 August 2021
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 HIV microtubule microtubule-associated proteins post-translational modifications tubulin The eukaryotic cell is structured in different membranous and non-membranous organelles that compartmentalize...
Biochem Soc Trans (2021) 49 (4): 1633–1641.
Published: 25 August 2021
... The Author(s) 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Ebola virus HIV lipid–protein interaction Marburg virus virus assembly virus budding...
Biochem Soc Trans (2019) 47 (4): 1013–1027.
Published: 11 July 2019
..., SAMHD1 also restricts the replication of several retroviruses, such as HIV-1, and some DNA viruses in dendritic and myeloid lineage cells and resting T-cells. SAMHD1 activity is regulated throughout the cell cycle, both at the level of protein expression and post-translationally, through phosphorylation...
Biochem Soc Trans (2017) 45 (3): 703–708.
Published: 15 June 2017
...Mickaël M. Ménager Dendritic cells (DCs) have essential roles in early detection of pathogens and activation of both innate and adaptive immune responses. Whereas human DCs are resistant to productive HIV-1 replication, they have a unique ability to take up virus and transmit it efficiently to T...
Biochem Soc Trans (2017) 45 (2): 353–364.
Published: 13 April 2017
...Laura Hidalgo; Chad M. Swanson Human immunodeficiency virus type 1 (HIV-1) mRNA translation is a complex process that uses the host translation machinery to synthesise viral proteins. Several mechanisms for HIV-1 mRNA translation initiation have been proposed including (1) cap-dependent, eIF4E...
Biochem Soc Trans (2016) 44 (5): 1417–1425.
Published: 19 October 2016
...Charlotte Mahiet; Chad M. Swanson Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3′-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding...
Biochem Soc Trans (2013) 41 (1): 277–282.
Published: 29 January 2013
.... Identification of an inhibitory budding signal that blocks the release of HIV particles and exosome/microvesicle proteins Mol. Biol. Cell 2011 22 817 830 20 Gan X. Gould S.J. HIV Pol inhibits HIV budding and mediates the severe budding defect of Gag-Pol PLoS ONE 2012 7 e29421 21...
Biochem Soc Trans (2011) 39 (5): 1427–1432.
Published: 21 September 2011
...Anna G. Drannik; Bethany M. Henrick; Kenneth L. Rosenthal Despite tremendous advances in our understanding of HIV/AIDS since the first cases were reported 30 years ago, we are still a long way from understanding critical steps of HIV acquisition, pathogenesis and correlates of protection. Our new...
Biochem Soc Trans (2009) 37 (1): 185–189.
Published: 20 January 2009
..., and the subsequent assembly and release of infectious virus particles, is co-coordinated through interactions between the viral structural proteins and cellular proteins. In the present paper, we consider how these events occur during HIV production in macrophages. In these cells, virus assembly appears to occur...
Biochem Soc Trans (2006) 34 (6): 997–1001.
Published: 25 October 2006
... may alter the receptor specificity and may result in up- or down-regulation of their chemotactic, antiviral or angiogenic activity. chemokine chemotaxis HIV inflammation post-translational modification protease Chemokines selectively attract leucocyte subsets and regulate the migration...
Biochem Soc Trans (2002) 30 (6): 1140–1145.
Published: 01 November 2002
... genetic disease HIV nucleolus DMPK, dystrophica myotonica-protein kinase MDM2, murine double minute 2 Ribozymes and RNA Catalysis: Focused Meeting Organized by D. M. J. Lilley (Department of Biochemistry, University of Dundee) and F. Eckstein (Max-Planck Institute for Experimental...