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Keywords: Golgi
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Articles
Biochem Soc Trans (2020) 48 (5): 1877–1888.
Published: 21 October 2020
... recently, its function remained unclear. AP-4 associates with the trans -Golgi network (TGN) through interaction with small GTPases of the ARF family and recognizes transmembrane proteins (i.e. cargos) having specific sorting signals in their cytosolic domains. Recent studies identified accessory proteins...
Includes: Multimedia, Supplementary data
Articles
Biochem Soc Trans (2016) 44 (6): 1603–1610.
Published: 02 December 2016
... accepted compared with those that are more controversial and indicate where aspects of LRRK2 biology still need to be clarified. autophagy Golgi human genetics kinase Rab GTPases vesicles In 2004, mutations were found in the leucine-rich repeat kinase 2 ( LRRK2 ) gene that caused...
Articles
Biochem Soc Trans (2015) 43 (1): 117–121.
Published: 26 January 2015
... the cytoskeleton dynamics with vesicle trafficking during cytokinesis are poorly understood. The highly conserved Golgi phosphoprotein 3 (GOLPH3), functions as a phosphatidylinositol 4-phosphate (PI4P) effector at the Golgi. Recent studies have suggested that GOLPH3 is up-regulated in several cancers...
Articles
Biochem Soc Trans (2012) 40 (2): 469–473.
Published: 21 March 2012
...Michelle L. Villasmil; Vytas A. Bankaitis; Carl J. Mousley The Kes1 OSBP (oxysterol-binding protein) is a key regulator of membrane trafficking through the TGN ( trans- Golgi network) and endosomal membranes. We demonstrated recently that Kes1 acts as a sterol-regulated rheostat for TGN/endosomal...
Articles
Biochem Soc Trans (2012) 40 (1): 205–209.
Published: 19 January 2012
...Hailan Piao; Peter Mayinger PtdIns4 P is a key regulator of the secretory pathway and plays an essential role in trafficking from the Golgi. Our recent work demonstrated that spatial control of PtdIns4 P at the ER (endoplasmic reticulum) and Golgi co-ordinates secretion with cell growth...
Articles
Biochem Soc Trans (2010) 38 (1): 177–180.
Published: 19 January 2010
...Marina Mikhaylova; Pasham Parameshwar Reddy; Michael R. Kreutz The regulated local synthesis of PtdIns4 P and PtdIns(4,5) P 2 is crucial for TGN ( trans -Golgi network)–plasma membrane trafficking. The activity of PI4Kβ (phosphoinositide 4-kinase IIIβ) at the Golgi membrane is a first mandatory...
Articles
Biochem Soc Trans (2005) 33 (6): 1276–1278.
Published: 26 October 2005
... are the most divergent and most studied human Arf proteins that localize predominantly to the Golgi complex and plasma membrane respectively. We have been studying the targeting of Arf1 and Arf6 to these specific compartments and the common and divergent activities that they exert on these membranes. We have...
Articles
Biochem Soc Trans (2005) 33 (6): 1265–1268.
Published: 26 October 2005
... that has been instrumental in deciphering the molecular principles of membrane traffic at the Golgi. BFA targets a low-affinity Arf–Sec7 intermediate of the exchange reaction. It binds at the Arf-GDP/Sec7 interface, thus freezing the complex in an abortive conformation that cannot proceed to nucleotide...
Articles
Biochem Soc Trans (2005) 33 (6): 1269–1272.
Published: 26 October 2005
... (Arl) cytokinesis Golgi membrane traffic microtubule Together, these results argue strongly for roles for Arf family members (at least Arl2, Arl3, Arl6 and Arl8) in these essential and microtubule-dependent cellular processes. Interestingly, there is also a growing appreciation of the fact...
Articles
Biochem Soc Trans (2005) 33 (4): 639–642.
Published: 01 August 2005
... activities at the Golgi and plasma membrane respectively. Chimaeras were made between Arf1 and Arf6 in order to identify regions of the protein that contributed to targeting and function. Whereas Arf6 is targeted to the plasma membrane through multiple regions along the protein, we have found a Golgi...
Articles
Biochem Soc Trans (2005) 33 (4): 643–645.
Published: 01 August 2005
... ARL stands for ARF-like) encoded in the T. brucei and T. cruzi genomes and ten in L. major . The T. brucei ARL1 protein is expressed only in the mammalian bloodstream form of the parasite, in which it is localized to the Golgi apparatus. RNAi (RNA interference) has been used to demonstrate that ARL1...
Articles
Biochem Soc Trans (2005) 33 (4): 623–626.
Published: 01 August 2005
... ). 3 3 2005 © 2005 The Biochemical Society 2005 Cdc42 Golgi guanine nucleotide-exchange factor (GEF) HeLa cell lamellipodiae Rho GDP dissociation inhibitor (rhoGDI) Small G-proteins of the Rho family regulate many features of the normal cell such as polarity, motility...
Articles
Biochem Soc Trans (2005) 33 (4): 657–661.
Published: 01 August 2005
... nascent Ras proteins transit endomembranes en route to the PM (plasma membrane) and that at steady-state N-Ras and H-Ras are highly expressed on the Golgi apparatus. To test the hypothesis that Ras proteins on internal membranes can signal, we developed a fluorescent probe that reports when and where...
Articles
Biochem Soc Trans (2005) 33 (4): 601–605.
Published: 01 August 2005
..., and which is localized to the Golgi in all species so far examined. The best-characterized effectors of Arl1 are coiled-coil proteins which share a C-terminal GRIP domain, but other apparent effectors include the GARP (Golgi-associated retrograde protein)/VFT (Vps fifty-three) vesicle-tethering complex...
Articles
Biochem Soc Trans (2005) 33 (4): 614–618.
Published: 01 August 2005
... that the requirement for dual prenylation is evolutionarily conserved [ 5 ]. Thus the di-geranylgeranylation of Rab proteins is more than just a ‘greasy tail’ for Rab proteins but adds a unique functionality that is necessary for the restricted compartmentalization of Rab proteins. Golgi prenylation Rab...
Articles
Biochem Soc Trans (2004) 32 (3): 520–523.
Published: 01 June 2004
...: a Biochemical Society Focused Meeting held at Rothamsted Research, Harpenden, 25 November 2003 25 November 2003 © 2004 Biochemical Society 2004 Golgi isotope-coded affinity tag (ICAT) membrane protein organelle quantitative proteomics Abbreviations used: 2D, two-dimensional...