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Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2253–2259.
Published: 14 October 2020
... glutathione GPX4 lipid peroxidation In 2014 Yang et al. [ 7 ] described the mode of action of RSL3, an unconventional compound inducing ferroptosis. RSL3, unlike erastin and BSO, was shown to directly inhibit glutathione peroxidase 4 (GPX4) without impacting on GSH levels — thus underscoring...