... of two surface GPCRs (G-protein-coupled receptors), P2Y 1 and P2Y 12 . Similar to most GPCRs, P2Y receptor activity is tightly regulated by a number of complex mechanisms including receptor desensitization, internalization and recycling. In the present article, we review the molecular mechanisms...

...Laurence J. Miller; Maoqing Dong Class B GPCRs (G-protein-coupled receptors) share heptahelical topology and G-protein binding with other superfamily members, yet have unique structures and modes of activation. Natural ligands for these receptors are moderate-length peptides with C-terminal α...

... arginine vasopressin CTR cephalotocin receptor GPCR G-protein-coupled receptor ICL intracellular loop OT oxytocin OTR oxytocin receptor TM transmembrane VT vasotocin The work on bioactive peptides in our laboratory was financially supported by the FWF...

...Hugo Gutiérrez-de-Terán; Xabier Bello; David Rodríguez The recent advances in membrane protein crystallography have provided extremely valuable structural information of the superfamily of GPCRs (G-protein-coupled receptors). This has been particularly true for a few receptors whose structure...