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Keywords: GPCR
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Biochem Soc Trans (2020) 48 (5): 2195–2203.
Published: 14 October 2020
...Gert N. Moll; Anneke Kuipers; Rick Rink; Tjibbe Bosma; Louwe de Vries; Pawel Namsolleck The conformation with which natural agonistic peptides interact with G protein-coupled receptor(s) (GPCR(s)) partly results from intramolecular interactions such as hydrogen bridges or is induced by ligand...
Biochem Soc Trans (2013) 41 (1): 159–165.
Published: 29 January 2013
..., U.K.) β 2 AR β 2 -adrenoceptor CL3 cytoplasmic loop 3 EL2 extracellular loop 2 GPCR G-protein-coupled receptor H transmembrane helix rmsd root mean square deviation T4L T4 lysozyme W water molecule Research in the laboratory of T.W...
Biochem Soc Trans (2013) 41 (1): 218–224.
Published: 29 January 2013
...Eamonn Kelly Ligand bias refers to the ability of a drug at a receptor to activate selectively particular cell signalling pathways over others, in a way that cannot be explained by traditional models of receptor theory. For a physiologically and therapeutically important GPCR (G-protein-coupled...
Biochem Soc Trans (2005) 33 (1): 253–256.
Published: 01 February 2005
..., is associated with low activity of the PKA pathway. We have studied how different nutrients trigger rapid activation of the pathway. Glucose and sucrose activate cAMP synthesis through a G-protein-coupled receptor system, consisting of the GPCR Gpr1, the Gα protein Gpa2 and its RGS protein Rgs2. Glucose is also...
Biochem Soc Trans (2001) 29 (4): 500–504.
Published: 01 August 2001
...M. von Zastrow Many G-protein-coupled receptors (GPCRs) undergo agonist-induced endocytosis. Endocytosis contributes to distinct processes that regulate the number and functional activity of receptors present in the plasma membrane, contributing to the well described processes of receptor...