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Keywords: G-quadruplex
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Biochem Soc Trans (2017) 45 (5): 1159–1171.
Published: 12 September 2017
...Alicia K. Byrd; Kevin D. Raney Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial DNA in eukaryotes. Saccharomyces cerevisiae Pif1 is involved in replication through barriers to replication, such as G-quadruplexes and protein blocks, and reduces genetic...
Biochem Soc Trans (2016) 44 (6): 1761–1768.
Published: 02 December 2016
...Carika Weldon; Ian C. Eperon; Cyril Dominguez The roles of deoxyribonucleic acid (DNA) G-quadruplex structures in gene expression and telomere maintenance have been well characterized. Recent results suggest that such structures could also play pivotal roles in ribonucleic acid (RNA) biology...
Biochem Soc Trans (2015) 43 (6): 1227–1233.
Published: 27 November 2015
...-proliferative/anti-malignant properties are substantiated. G-quadruplexes are four-stranded structures comprised of stacks of Hoogsteen hydrogen bonded G-tetrads and can form within G-rich regions of both DNA and RNA. There is growing interest in the role of RNA G-quadruplexes in RNA biology as they have...
Biochem Soc Trans (2015) 43 (3): 338–342.
Published: 01 June 2015
...James P.R. Schofield; Joanne L. Cowan; Mark J. Coldwell There has recently been a huge increase in interest in the formation of stable G-quadruplex structures in mRNAs and their functional significance. In neurons, local translation of mRNA is essential for normal neuronal behaviour. It has been...
Biochem Soc Trans (2011) 39 (2): 635–640.
Published: 22 March 2011
...Robert V. Brown; Laurence H. Hurley Over the last decade or so, secondary non-B-DNA structures such as G-quadruplexes and i-motifs have come into focus as biologically functioning moieties that are potentially involved in telomeric interactions and the control of gene expression. In the present...
Biochem Soc Trans (2009) 37 (3): 583–588.
Published: 20 May 2009
..., termed a G-quartet. Several G-quartets can stack on top of another, to form a four-stranded G-quadruplex arrangement, with the G-quartets held together by nucleotides from the sequences that occur between each G-tract. Quadruplexes can be formed by the folding of a single contiguous sequence containing...
Biochem Soc Trans (2001) 29 (6): 692–696.
Published: 01 November 2001
... and to stabilize specific secondary structures. Dependent upon the primary DNA sequence, purine- and pyrimidine-rich strands of DNA can adopt four-stranded structures known as G-quadruplexes and i-motifs, respectively. These structures have been proposed to exist in biologically important regions of DNA, e.g...