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Keywords: G-quadruplex
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Biochem Soc Trans (2023) 51 (1): 403–413.
Published: 11 January 2023
... of the Biochemical Society 2023 G-quadruplex nucleolin topoisomerases Guanine-rich nucleic acid sequences can fold into non-canonical four-stranded DNA structures referred to as G-quadruplexes or G4 DNAs [ 1 , 2 ]. G4 DNAs consist of G-quartets formed from four guanine molecules interacting via...
Biochem Soc Trans (2017) 45 (5): 1159–1171.
Published: 12 September 2017
...Alicia K. Byrd; Kevin D. Raney Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial DNA in eukaryotes. Saccharomyces cerevisiae Pif1 is involved in replication through barriers to replication, such as G-quadruplexes and protein blocks, and reduces genetic...
Biochem Soc Trans (2015) 43 (6): 1227–1233.
Published: 27 November 2015
...-dependent translation by specifically inhibiting eIF4A activity. All appear to act non-specifically upon eIF4A1 and eIF4A2. G-quadruplexes are four-stranded structures comprised of stacks of Hoogsteen hydrogen bonded G-tetrads and can form within G-rich regions of both DNA and RNA. There is growing...
Biochem Soc Trans (2015) 43 (3): 338–342.
Published: 01 June 2015
...James P.R. Schofield; Joanne L. Cowan; Mark J. Coldwell There has recently been a huge increase in interest in the formation of stable G-quadruplex structures in mRNAs and their functional significance. In neurons, local translation of mRNA is essential for normal neuronal behaviour. It has been...
Biochem Soc Trans (2011) 39 (2): 635–640.
Published: 22 March 2011
...Robert V. Brown; Laurence H. Hurley Over the last decade or so, secondary non-B-DNA structures such as G-quadruplexes and i-motifs have come into focus as biologically functioning moieties that are potentially involved in telomeric interactions and the control of gene expression. In the present...
Biochem Soc Trans (2009) 37 (3): 583–588.
Published: 20 May 2009
... a four-stranded G-quadruplex arrangement, with the G-quartets held together by nucleotides from the sequences that occur between each G-tract. Quadruplexes can be formed by the folding of a single contiguous sequence containing multiple G-tracts (unimolecular) or by the association of two or four...
Biochem Soc Trans (2001) 29 (6): 692–696.
Published: 01 November 2001
... and to stabilize specific secondary structures. Dependent upon the primary DNA sequence, purine- and pyrimidine-rich strands of DNA can adopt four-stranded structures known as G-quadruplexes and i-motifs, respectively. These structures have been proposed to exist in biologically important regions of DNA, e.g...