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Keywords: G-protein-coupled receptor (GPCR)
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Articles
Biochem Soc Trans (2016) 44 (2): 574–581.
Published: 11 April 2016
...-based drug discovery (SBDD) process. Clearly, to begin SBDD, a structure is needed, and although there has been fantastic progress in solving G-protein-coupled receptor (GPCR) crystal structures, the process remains quite slow and is not currently feasible for every GPCR or GPCR–ligand complex...
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Biochem Soc Trans (2016) 44 (2): 619–623.
Published: 11 April 2016
...Mark Wheatley; Jack Charlton; Mohammed Jamshad; Sarah J. Routledge; Sian Bailey; Penelope J. La-Borde; Maria T. Azam; Richard T. Logan; Roslyn M. Bill; Tim R. Dafforn; David R. Poyner G-protein-coupled receptors (GPCRs) form the largest class of membrane proteins and are an important target...
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Biochem Soc Trans (2016) 44 (2): 595–600.
Published: 11 April 2016
...Verònica Casadó-Anguera; Jordi Bonaventura; Estefanía Moreno; Gemma Navarro; Antoni Cortés; Sergi Ferré; Vicent Casadó Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel targets for drug development. Accumulating evidence indicates that GPCRs can form homodimers...
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Biochem Soc Trans (2014) 42 (2): 257–264.
Published: 20 March 2014
.... Consistent with this, a cAMP-responsive signalling complex that includes Epac1 and PDE4D3 has been identified in cardiac myocytes [ 28 ]. cAMP cardiac disease exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor (GPCR) heart failure phosphodiesterase cAMP...
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Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology What of the future? Arising from the meeting, we think that it is possible to see a number of important areas for future research in GPCR biology. The crystal structures are wonderfully revealing, but provide...
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Biochem Soc Trans (2013) 41 (1): 89–94.
Published: 29 January 2013
... be dynamically regulated, it is now widely accepted that repeated cycles of palmitoylation and depalmitoylation could have important functional consequences for signalling [ 1 , 2 ]. 1 To whom correspondence should be addressed (e-mail ponimaskin.evgeni@mh-hannover.de ). G-protein-coupled receptor...
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Biochem Soc Trans (2012) 40 (2): 383–388.
Published: 21 March 2012
... ). 6 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 adenosine receptor adrenergic receptor G-protein-coupled receptor (GPCR) metarhodopsin-II retinal rhodopsin GPCRs (G-protein-coupled receptors) are a family of seven-transmembrane helix proteins...
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Biochem Soc Trans (2012) 40 (2): 389–393.
Published: 21 March 2012
... sensitive dim-light photoreceptor in vertebrates, as well as the common elements that it shares with the large class A GPCR family. However, despite progress, a number of questions remain unanswered about how these receptors are activated. G-protein-coupled receptor (GPCR) retinal chromophore rhodopsin...
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Biochem Soc Trans (2011) 39 (3): 725–732.
Published: 20 May 2011
... crystallization G-protein-coupled receptor (GPCR) lipidic cubic phase macromolecular crystallography membrane protein structure mesophase robot structure–function analysis The 13 January 2011 issue of the journal Nature includes three papers reporting on the structure and function of medically...
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Biochem Soc Trans (2010) 38 (5): 1275–1280.
Published: 24 September 2010
... G-protein-coupled receptor (GPCR) kinetic modelling Leber congenital amaurosis phototransduction rod systems biology The primary events in vertebrate vision are the biochemical steps in the phototransduction cascade in rods and cones, the retinal photoreceptor cells. This signal...
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Biochem Soc Trans (2007) 35 (5): 1191–1194.
Published: 25 October 2007
... Journal compilation © 2007 Biochemical Society 2007 enteroendocrine cell G-protein-coupled receptor (GPCR) gut hormone intestinal glucose sensing sodium/glucose co-transporter 1 (SGLT1) taste receptor Glucose in the lumen of the intestine evokes various changes in gastrointestinal function...
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Biochem Soc Trans (2007) 35 (5): 985–990.
Published: 25 October 2007
... 45 9906 9918 amyloid cross-polarization magic-angle spinning (CP-MAS) drug discovery G-protein-coupled receptor (GPCR) NMR solid-state NMR There are now numerous examples of how the search for new drug candidates has been hastened by structural information provided by X-ray...
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Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor Fluorescence techniques can provide complementary insights into the environment of indicators that can be situated at distinct sites throughout...
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Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
.... Dalrymple M.B. Lim E.M.L. Thomas W.G. Eidne K.A. Cell. Signalling 2006 18 1664 1670 β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging protein–protein interaction There are clearly important...
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Biochem Soc Trans (2007) 35 (4): 749–754.
Published: 20 July 2007
... 1 To whom correspondence should be addressed (email C.A.Reynolds@essex.ac.uk ). 4 5 2007 cold-spot alignment evolutionary trace G-protein-coupled receptor (GPCR) GCR1 Molecular Dynamics simulations receptor dimerization Family B G-protein coupled receptor (GPCRs...
Includes: Supplementary data
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Biochem Soc Trans (2007) 35 (4): 707–708.
Published: 20 July 2007
... articles. 11 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 drug design G-protein-coupled receptor (GPCR) ligand binding molecular modelling receptor activation This following collection of articles are based on talks given at the Biochemical Society...
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Biochem Soc Trans (2007) 35 (4): 713–716.
Published: 20 July 2007
...) glucagon-like peptide receptor 1 (GLP1-R) G-protein-coupled receptor (GPCR) peptide binding Type 2 diabetes In order to better understand how GLP-1 [glucagon-like peptide-1-(7–36)-amide] and its analogues bind and activate the GLP-1R (GLP-1 receptor), our group have spent several years...
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Biochem Soc Trans (2007) 35 (4): 733–736.
Published: 20 July 2007
... efficacy D 2 dopamine receptor G-protein-coupled receptor (GPCR) G-protein cycle guanosine 5′-[γ-[ 35 S]thio]triphosphate-binding assay ([ 35 S]GTP[S]-binding assay) kinetics Nevertheless, it is important to ask whether the relative efficacy values determined using this assay reflect relative...
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Biochem Soc Trans (2007) 35 (4): 717–720.
Published: 20 July 2007
... of Life Sciences, University of Wales, Swansea SA2 8PP, U.K. 27 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 agonist G-protein-coupled receptor (GPCR) peptide hormone receptor activation vasopressin GPCRs (G-protein-coupled receptors...
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Biochem Soc Trans (2007) 35 (4): 737–741.
Published: 20 July 2007
... 2007 agonist selectivity bivalent ligand G-protein-coupled receptor (GPCR) oxytocin therapeutic agent vasopressin OT (oxytocin) and AVP (vasopressin) receptors belong to the superfamily of GPCRs (G-protein coupled receptors), which are integral membrane proteins characterized...
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Biochem Soc Trans (2007) 35 (1): 23–27.
Published: 22 January 2007
... © 2007 The Biochemical Society 2007 angiotensin receptor β-adrenoceptor G-protein G-protein-coupled receptor (GPCR) melatonin receptor protein network The first group of GPCRs (G-protein-coupled receptors) to be well characterized were the β-adrenoceptors, of which there are three...
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Biochem Soc Trans (2006) 34 (6): 1095–1097.
Published: 25 October 2006
... for neuroprotective treatment. 1 To whom correspondence should be addressed (email stxys3@nottingham.ac.uk ). 20 7 2006 © 2006 The Biochemical Society 2006 cannabinoid receptor (CB receptor) central nervous system (CNS) G-protein-coupled receptor (GPCR) middle cerebral artery occlusion...
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Biochem Soc Trans (2005) 33 (6): 1362–1365.
Published: 26 October 2005
... provide new and useful targets for preventive or therapeutic measures. 1 To whom correspondence should be addressed (email sspiegel@vcu.edu ). 23 6 2005 © 2005 The Biochemical Society 2005 acylglycerol kinase epidermal growth factor (EGF) G-protein-coupled receptor (GPCR...
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Biochem Soc Trans (2005) 33 (5): 1131–1134.
Published: 26 October 2005
...P.A. Insel; B.P. Head; H.H. Patel; D.M. Roth; R.A. Bundey; J.S. Swaney G-protein-coupled receptors (GPCRs) and post-GPCR signalling components are expressed at low overall abundance in plasma membranes, yet they evoke rapid, high-fidelity responses. Considerable evidence suggests that GPCR...
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Biochem Soc Trans (2004) 32 (6): 1029–1031.
Published: 26 October 2004
... it is possible that GRK phosphorylation of GPCRs depends on an additional conformational change in the receptor, which is not required for either G-protein activation or arrestin binding. © 2004 The Biochemical Society 2004 arrestin fluorescence resonance energy transfer (FRET) G-protein-coupled...
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Biochem Soc Trans (2004) 32 (6): 1037–1039.
Published: 26 October 2004
... cAMP regulatory element (CRE)-luciferase glucagon G-protein-coupled receptor (GPCR) mutagenesis receptor activation ternary complex The extended ternary complex model for GPCR (G-protein-coupled receptor) activation suggests that they interchange between inactive (R) and active (R*) states...
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Biochem Soc Trans (2004) 32 (2): 383–386.
Published: 01 April 2004
..., these data suggested expression of PI3K not only in blood vessels but also in cardiac muscle. Evidence supporting this hypothesis included the finding Key words: -adrenergic receptor, contractility, G-protein-coupled receptor (GPCR), heart disease, hypertrophy, phosphoinositide 3-kinase (PI3K...
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Biochem Soc Trans (2003) 31 (6): 1216–1219.
Published: 01 December 2003
... and immunoregulation. Other studies, however, suggested that S1P also has second messenger functions important for regulation of calcium Key words: cell growth and survival, G-protein-coupled receptor (GPCR), sphingosine kinase, sphingosine 1-phosphate (S1P), sphingosine 1-phosphate receptor, tetrahydrobiopterin...
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Biochem Soc Trans (2003) 31 (6): 1203–1208.
Published: 01 December 2003
... (ADAM) cancer cross-talk epidermal growth factor receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK...