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Biochem Soc Trans (2014) 42 (4): 873–877.
Published: 11 August 2014
... that enhances the sexual behaviour of female mice via the VNO. NMR studies demonstrate that ESP1 adopts a compact structure with a helical fold stabilized by an intramolecular disulfide bridge. Functional analysis in combination with docking simulation indicates that ESP1 is recognized by a specific G-protein...
Biochem Soc Trans (2014) 42 (2): 239–243.
Published: 20 March 2014
...Markus Milde; Ruth C. Werthmann; Kathrin von Hayn; Moritz Bünemann A wide variety of G-protein-coupled receptors either activate or inhibit ACs (adenylate cyclases), thereby regulating cellular cAMP levels and consequently inducing proper physiological responses. Stimulatory and inhibitory G...
Biochem Soc Trans (2014) 42 (1): 206–211.
Published: 23 January 2014
...Robert A. Arkowitz; Martine Bassilana Rho G-proteins and phosphatidylinositol phosphates, which are important for exocytosis, endocytosis and cytoskeleton organization, are key regulators of polarized growth in a range of organisms. The aim of the present brief review is to highlight recent...
Sophie Mary, Jean-Alain Fehrentz, Marjorie Damian, Pascal Verdié, Jean Martinez, Jacky Marie, Jean-Louis Banères
Biochem Soc Trans (2013) 41 (1): 144–147.
Published: 29 January 2013
...Sophie Mary; Jean-Alain Fehrentz; Marjorie Damian; Pascal Verdié; Jean Martinez; Jacky Marie; Jean-Louis Banères The dynamic character of GPCRs (G-protein-coupled receptors) is essential to their function. However, the details of how ligands and signalling proteins stabilize a receptor conformation...
Biochem Soc Trans (2013) 41 (1): 231–236.
Published: 29 January 2013
... are supported by G-protein-independent, β-arrestin-dependent signalling events. In the present article, we review current knowledge on structural and signalling properties of ACRs that are changing our view on this entire class of receptors from silent to endogenous β-arrestin-biased signalling receptors...
Biochem Soc Trans (2012) 40 (6): 1337–1347.
Published: 21 November 2012
...Eoin E. Kelly; Conor P. Horgan; Bruno Goud; Mary W. McCaffrey Intracellular membrane trafficking requires the complex interplay of several classes of trafficking proteins. Rab proteins, the largest subfamily of the Ras superfamily of small G-proteins, are central regulators of all aspects...
Bruck Taddese, Lisa M. Simpson, Ian D. Wall, Frank E. Blaney, Nathan J. Kidley, Henry S.X. Clark, Richard E. Smith, Graham J.G. Upton, Paul R. Gouldson, George Psaroudakis, Robert P. Bywater, Christopher A. Reynolds
Biochem Soc Trans (2012) 40 (2): 394–399.
Published: 21 March 2012
... are compared with recently published X-ray crystallographic structures of activated GPCRs (G-protein-coupled receptors). These molecular dynamics-based models using experimental data derived from biophysical experiments on activation were used to restrain the receptor to an active state that gave high...
Includes: Supplementary data
Biochem Soc Trans (2012) 40 (1): 200–204.
Published: 19 January 2012
... and adipoQ receptors), which include receptors for adiponectin in vertebrates and osmotin in fungi. mPRs have been shown to activate inhibitory G-proteins, suggesting that they act as GPCRs (G-protein-coupled receptors). However, PAQRs do not resemble GPCRs with respect to topology or conserved sequence...
Biochem Soc Trans (2008) 36 (4): 653–657.
Published: 22 July 2008
...; substitution of the aspartate residues did not affect the rate of GTP hydrolysis. This is consistent with the NMR data, which showed the largest changes in chemical shifts in the two isoleucine residues upon binding of DIDDI to eIF5B [ 47 ]. G-protein initiation factor ribosomal subunit joining...
Biochem Soc Trans (2008) 36 (4): 658–664.
Published: 22 July 2008
...Sarah S. Mohammad-Qureshi; Martin D. Jennings; Graham D. Pavitt A variety of cellular processes rely on G-proteins, which cycle through active GTP-bound and inactive GDP-bound forms. The switch between these states is commonly regulated by GEFs (guanine-nucleotide-exchange factors) and GAPs (GTPase...
Biochem Soc Trans (2008) 36 (3): 381–383.
Published: 21 May 2008
... and the heterotrimeric G-proteins GOA-1/GPA-16 and their regulator GPR-1/2 causes defects in aster-positioned cytokinesis but not in midzone-positioned cytokinesis. In order to understand aster-positioned cytokinesis we have to understand how microtubule asters spatially control the activity of LET-99, GPR-1/2 and GOA-1...
Biochem Soc Trans (2007) 35 (5): 1035–1037.
Published: 25 October 2007
...M. Sato; D.S. Hutchinson; B.A. Evans; R.J. Summers Localization of G-protein-coupled receptors within membrane microdomains is associated with differential signalling pathway activation. We have shown that two mouse β 3 -AR (β 3 -adrenoceptor) isoforms encoded by alternatively spliced mRNAs differ...
Biochem Soc Trans (2007) 35 (4): 729–732.
Published: 20 July 2007
...A.C. Conner; J. Simms; J. Barwell; M. Wheatley; D.R. Poyner The receptor for CGRP (calcitonin gene-related peptide) is a heterodimer between a GPCR (G-protein-coupled receptor), CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity-modifying protein 1). Models...
Biochem Soc Trans (2007) 35 (1): 23–27.
Published: 22 January 2007
...A.D. Strosberg; C. Nahmias This short review provides a broad, and therefore necessarily incomplete and personal, overview of G-protein-coupled receptors, which are often targets for a wide range of important drugs: I will discuss successively their structure, function and interactions...
Biochem Soc Trans (2006) 34 (4): 515–517.
Published: 21 July 2006
...S.C. Tovey; S.G. Dedos; C.W. Taylor PTH (parathyroid hormone), acting via type 1 PTH receptors, is a major regulator of plasma [Ca 2+ ]. The G-protein, G s , is an essential component of the sequence linking PTH to plasma Ca 2+ regulation, but the relative importance of intracellular signals...
Biochem Soc Trans (2006) 34 (2): 213–216.
Published: 20 March 2006
... but may bind transiently to it to promote individual steps of the mRNA translation process. eukaryotic initiation factor (eIF) G-protein insulin mRNA translation mammalian target of rapamycin (mTOR) tuberous sclerosis complex (TSC) © 2006 The Biochemical Society 2006 14 9 2005...
Biochem Soc Trans (2005) 33 (4): 619–622.
Published: 01 August 2005
...B. Antonny; J. Bigay; J.-F. Casella; G. Drin; B. Mesmin; P. Gounon The GTP switch of the small G-protein Arf1 (ADP-ribosylation factor 1) on lipid membranes promotes the polymerization of the COPI (coat protein complex I) coat, which acts as a membrane deforming shell to form transport vesicles...
Biochem Soc Trans (2005) 33 (1): 257–260.
Published: 01 February 2005
...C.S. Hoffman The fission yeast Schizosaccharomyces pombe primarily detects glucose via a cAMP-signalling pathway. Components of this pathway include the Git3 G-protein-coupled receptor and a heterotrimeric G-protein, from which the Gpa2 Gα subunit activates adenylate cyclase (Git2/Cyr1). Three...
Biochem Soc Trans (2004) 32 (5): 878–880.
Published: 26 October 2004
...G. Milligan; H. Murdoch; E. Kellett; J.H. White; G.-J. Feng A substantial number of G-protein-coupled receptor-interacting proteins have been identified initially by the use of yeast two-hybrid screens. Using the C-terminal tail of both opioid receptors and the melanin concentrating hormone...
Biochem Soc Trans (2004) 32 (2): 387–392.
Published: 01 April 2004
... in maintaining the integrity of the vascular system (reviewed in [6 Key words: adhesion, G-protein, integrin IIb 3, phosphoinositide 3-kinase (PI 3-kinase), phospholipase C 2, platelet. Abbreviations used: CRP, collagen-related peptide; GPIb (etc glycoprotein Ib (etc ITAM, immunoreceptor tyrosine-based...
Biochem Soc Trans (2003) 31 (1): 29–34.
Published: 01 February 2003
... 6 September 2002 Copyright 2003 Biochemical Society 2003 G-protein G-protein-coupled receptor rhodopsin Abbreviations used: ACh, acetylcholine; mAChR, muscarinic acetylcholine receptor; NMS, N -methyl scopolamine; TM, transmembrane. Signalling the Future 29 Structure...
D. A. McCulloch, C. J. MacKenzie, M. S. Johnson, D. N. Robertson, P. J. Holland, E. Ronaldson, E. M. Lutz, R. Mitchell
Biochem Soc Trans (2002) 30 (4): 441–446.
Published: 01 August 2002
... be addressed (e-mail Rory.Mitchell@ed.ac.uk ) 13 3 2002 © 2002 Biochemical Society 2002 ADP-ribosylation factor G-protein phospholipases C/D pituitary adenylate cyclase-activating polypeptide (PACAP) vasoactive intestinal polypeptide (VIP) ARF, ADP-ribosylation factor ERK...