...Monica Napolitano The G protein-coupled receptors (GPCRs) constitute a large superfamily of seven transmembrane-spanning receptors that are activated by several classes of ligands, including bioactive lipids. GPCRs are attractive therapeutic targets for the treatment of human diseases...

... correspondence should be addressed (email richard.carr.3rd@gmail.com ). 25 11 2015 © 2016 Authors; published by Portland Press Limited 2016 biased signalling drug discovery G protein-coupled receptors pepducins polypharmacology G protein-coupled receptors (GPCRs) are the largest...

... (G-protein-coupled receptors), the existence of protein aggregates such as oligomers or clusters has been the topic of extensive debate. One of the reasons for this lively argument is that the molecular size is below the diffraction-limited resolution of the conventional microscopy, precluding...