... in the Fam20 family of kinases: D(N/H)(A/G) (Asp-Asn/His-Ala-Gly) ( Figure 1 ). Mutation of this aspartate residue in Fam20C abolished its activity, consistent with an important function in binding Mn 2+ [ 17 ]. Most protein kinases feature two non-consecutive hydrophobic structures referred to as ‘spines...