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Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 1061–1065.
Published: 18 July 2013
... in the Fam20 family of kinases: D(N/H)(A/G) (Asp-Asn/His-Ala-Gly) ( Figure 1 ). Mutation of this aspartate residue in Fam20C abolished its activity, consistent with an important function in binding Mn 2+ [ 17 ]. Most protein kinases feature two non-consecutive hydrophobic structures referred to as ‘spines...