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Keywords: ER stress
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Biochem Soc Trans (2024) 52 (2): 831–848.
Published: 11 April 2024
...Ethan Thibault; Federica Brandizzi Homeostasis of the endoplasmic reticulum (ER) is critical for growth, development, and stress responses. Perturbations causing an imbalance in ER proteostasis lead to a potentially lethal condition known as ER stress. In ER stress situations, cell-fate decisions...
Biochem Soc Trans (2021) 49 (4): 1841–1853.
Published: 02 August 2021
... protein response (UPR) is necessary. UPR followed by cell surface exposure of calreticulin on the dying tumor cell is essential for its engulfment by macrophages and dendritic cells. However, some tumor cells upon endoplasmic reticulum (ER) stress can release factors that induce ER stress to other cells...
Biochem Soc Trans (2021) 49 (3): 1251–1263.
Published: 18 May 2021
... and regulates genes involved in cell cycle and proliferation [ 42 ]. Sp1 has been shown to have a dual role in regulating the UPR in Panc-1 cells; it is required for GRP78 activation by ER stress and, in the same cell line, is required for the induction of UPR genes via binding to ER stress response elements...
Includes: Supplementary data