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Keywords: Drosophila
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Articles
Biochem Soc Trans (2022) BST20220325.
Published: 09 November 2022
...Hao Deng; Gaochen Jin; Bomyi Lim Proper enhancer–promoter interactions are essential to maintaining specific transcriptional patterns and preventing ectopic gene expression. Drosophila is an ideal model organism to study transcriptional regulation due to extensively characterized regulatory regions...
Articles
Biochem Soc Trans (2020) 48 (2): 367–377.
Published: 20 March 2020
... focus on the importance of the fruit fly Drosophila as a powerful model system to study redox processes in vivo . Correspondence: Helena M. Cochemé ( helena.cocheme@lms.mrc.ac.uk ) 9 12 2019 23 2 2020 25 2 2020 © 2020 The Author(s) 2020 This is an open access article...
Articles
Biochem Soc Trans (2016) 44 (2): 447–451.
Published: 11 April 2016
...) and the endoplasmic reticulum (ER) in Drosophila photoreceptors. Further, we discuss the role of specific proteins present at this location in regulating phospholipid turnover and its impact in regulating a physiological process, namely phototransduction. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2015) 43 (1): 117–121.
Published: 26 January 2015
... and is associated with poor prognosis and more aggressive tumours. In Drosophila melanogaster , GOLPH3 localizes at the cleavage furrow of dividing cells, is required for successful cytokinesis and acts as a key molecule in coupling phosphoinositide (PI) signalling with actomyosin ring dynamics. Because cytokinesis...
Articles
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Tra2 proteins are nuclear RNA-binding proteins involved in splicing regulation ( Figure 1 A). Tra2 proteins are conserved across the animal kingdom. Invertebrates have a single Tra2 protein copy (of which...
Articles
Biochem Soc Trans (2014) 42 (4): 1159–1167.
Published: 11 August 2014
... Biochemical Society 2014 DNA-binding protein Drosophila evolution of DNA innate immunity RNA editing RNA modification History does not repeat itself, but it rhymes. Mark Twain ADAR (adenosine deaminase acting on RNA) enzymes deaminate adenosine bases to inosines in cellular...
Articles
Biochem Soc Trans (2012) 40 (5): 1047–1051.
Published: 19 September 2012
... and degeneration of dopaminergic and other neuronal types. The molecular and cellular mechanisms underlying LRRK2 action remain poorly defined. Synaptic dysfunction has been increasingly recognized as an early event in the pathogenesis of major neurological disorders. Using Drosophila as a model system, we have...
Articles
Biochem Soc Trans (2012) 40 (4): 739–745.
Published: 20 July 2012
... patients. Many groups have independently developed Drosophila models of HD, taking advantage of its rapid life cycle, carefully annotated genome and well-established molecular toolkits. Furthermore, unlike simpler models, Drosophila have a complex nervous system, displaying a range of carefully co...
Articles
Biochem Soc Trans (2012) 40 (4): 891–895.
Published: 20 July 2012
... the amount of mRNA that can be translated into functional protein. One of the most important discoveries in this field has been miRNAs (microRNAs) and their function in targeting specific mRNAs for repression. The wing imaginal discs of Drosophila are an excellent model system to study the roles of miRNAs...
Articles
Biochem Soc Trans (2011) 39 (5): 1197–1201.
Published: 21 September 2011
... mediated by cytoskeletal elements (microtubules and actin filaments) and associated mechanoenzymes. Among the best-studied model systems of RNA localization are the oocyte and the early embryo of Drosophila melanogaster , for which many well-characterized tools have been developed to study this cell...
Articles
Biochem Soc Trans (2011) 39 (1): 378–382.
Published: 19 January 2011
... cell adhesion double-stranded RNA (dsRNA) Drosophila extracellular matrix (ECM) O-glycosylation tumour Mucin-type O-glycosylation is an evolutionarily conserved and widespread post-translational modification of proteins initiated by a family of enzymes known as the UDP-GalNAc:polypeptide...
Articles
Biochem Soc Trans (2010) 38 (4): 981–987.
Published: 26 July 2010
... hyperphosphorylation mediates toxicity or dysfunction in a cell-type-specific manner. Pan-neuronal accumulation of tau in the Drosophila CNS (central nervous system) specifically affected the MBs (mushroom body neurons), consistent with neuronal type-specific effects. The MB aberrations depended, at least in part...
Articles
Biochem Soc Trans (2010) 38 (4): 988–992.
Published: 26 July 2010
... and Aβ become abnormal is not clearly understood, neither is it known what role either protein plays in the neurodegenerative process underlying AD. We have modelled aspects of AD in Drosophila melanogaster to shed light on these processes and to further our understanding of the relationship between tau...
Articles
Biochem Soc Trans (2010) 38 (4): 1137–1143.
Published: 26 July 2010
... verification of biologically important targets at present requires experimental analysis. The present review aims to outline the mechanisms of mRNA degradation and then focus on the role of microRNAs as factors affecting particular Drosophila developmental processes via their post-transcriptional effects...
Articles
Biochem Soc Trans (2009) 37 (6): 1404–1406.
Published: 19 November 2009
... graduate studentship to I.McG. References 1 Ffrench-Constant R.H. Mortlock D.P. Shaffer C.D. MacIntyre R.J. Roush R.T. Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate γ-aminobutyric acid subtype A receptor locus Proc. Natl. Acad...
Articles
Biochem Soc Trans (2009) 37 (1): 204–207.
Published: 20 January 2009
... in yeast. Recent genetic studies in Drosophila have revealed the phenotypic consequences of loss of vps function in multicellular organisms. In the present paper, we review these studies and discuss a mechanism which may explain how loss of the human Tsg101 (tumour susceptibility gene 101), a vps23...
Articles
Biochem Soc Trans (2009) 37 (1): 232–236.
Published: 20 January 2009
... containing the serine/threonine protein kinase Atg1. Recent work in Drosophila and mammalian systems suggests that this complex and its regulation by TOR are conserved in higher eukaryotes, and that Atg1 has accrued additional functions including feedback regulation of TOR itself. TOR and Atg1 also control...
Articles
Biochem Soc Trans (2008) 36 (5): 868–873.
Published: 19 September 2008
... in vivo . In the present paper, we have compiled what is known about SUMOylation in Drosophila melanogaster , where the use of genetics provides new insights on SUMOylation's biological roles. 1 To whom correspondence should be addressed (email rbarrio@cicbiogune.es ). 4 3 2008 ©...
Articles
Biochem Soc Trans (2008) 36 (3): 540–542.
Published: 21 May 2008
...Carine Barreau; Elizabeth Benson; Helen White-Cooper Post-meiotic transcription is widespread in mammalian spermatogenesis, but is generally believed to be absent from Drosophila spermatogenesis. Genes required during meiosis, in early spermatids or later in spermiogenesis are typically transcribed...
Articles
Biochem Soc Trans (2007) 35 (6): 1496–1500.
Published: 23 November 2007
...K. Aggrawal; N. Silverman Drosophila rely primarily on innate immune responses to effectively combat a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of AMPs (antimicrobial peptides) by the fat body, the insect homologue...
Articles
Biochem Soc Trans (2007) 35 (5): 1215–1217.
Published: 25 October 2007
..., e.g. LAT1 (L-type amino acid transporter 1). Studies in Drosophila have also identified tissue-specific roles for AATs in TOR regulation. In particular, the putative CD98 light chain, minidiscs and the cationic amino acid transporter, Slif (Slimfast; discussed in [ 7 ]) have both been implicated...
Articles
Biochem Soc Trans (2007) 35 (2): 219–221.
Published: 20 March 2007
... is a characteristic feature of diabetes and many forms of human cancer. Recent molecular genetic studies initiated in the fruitfly, Drosophila melanogaster , have highlighted two new cell-type-specific mechanisms regulating PI3K/Akt signalling and its downstream effects. First, the cellular response to this cassette...
Articles
Biochem Soc Trans (2006) 34 (4): 512–514.
Published: 21 July 2006
...S.-A. Davies; J.P. Day The biochemical aspects of cGMP signalling are well known, although in vivo roles of cGMP have only been recently discovered through work in genetic model organisms. The Drosophila melanogaster Malpighian (renal) tubule has been used to address the roles of cGMP in epithelial...
Articles
Biochem Soc Trans (2006) 34 (1): 88–90.
Published: 20 January 2006
...F. Chee; A. Mudher; T.A. Newman; M. Cuttle; S. Lovestone; D. Shepherd Synaptic dysfunction is believed to be an early pathological change in neurodegenerative diseases and may cause the earliest clinical symptoms. We have used Drosophila to model a tauopathy in order to analyse the earliest...
Articles
Biochem Soc Trans (2005) 33 (5): 962–966.
Published: 26 October 2005
... in zebrafish, mammalian cell lines and, more recently, mammalian tissues, this view has changed to one where clock organization is now seen as being highly decentralized. It is clear that clocks exist in the peripheral tissues of animals as diverse as Drosophila , zebrafish and mammals. In the case...
Articles
Biochem Soc Trans (2005) 33 (6): 1444–1446.
Published: 26 October 2005
... to be an important mechanism of regulating spatial and temporal patterns of gene expression. PP1 (protein phosphatase-1), a major class of serine/threonine protein phosphatase, is found at many sites on Drosophila polytene chromosomes where it is involved in controlling gene expression and chromatin structure. PP1...
Articles
Biochem Soc Trans (2005) 33 (6): 1544–1546.
Published: 26 October 2005
...P. Lasko; P. Cho; F. Poulin; N. Sonenberg Translational control is a key genetic regulatory mechanism underlying the initial establishment of the major spatial axes of the Drosophila embryo. Many translational control mechanisms target eIF4E (eukaryotic initiation factor 4E), an initiation factor...
Articles
Biochem Soc Trans (2003) 31 (3): 659–663.
Published: 01 June 2003
...M. Gangloff; A.N.R. Weber; R.J. Gibbard; N.J. Gay The Toll receptor was first found to function in the dorsoventral patterning pathway of Drosophila embryos. It is activated by a specific protein ligand, Spätzle, generated at ventral positions in the early embryo. Drosophila Toll (dToll) also...