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Keywords: DNA repair
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Articles
Biochem Soc Trans (2024) 52 (1): 367–377.
Published: 07 February 2024
... 10 1 2024 12 1 2024 © 2024 The Author(s) 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . DNA repair helicases homologous recombination...
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Biochem Soc Trans (2023) 51 (3): 1307–1317.
Published: 07 June 2023
...Dmitri Ivanov; Taejoo Hwang; Lukasz Karol Sitko; Semin Lee; Anton Gartner Cells constantly accumulate mutations, which are caused by replication errors, as well as through the action of endogenous and exogenous DNA-damaging agents. Mutational patterns reflect the status of DNA repair machinery...
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Biochem Soc Trans (2020) 48 (2): 677–691.
Published: 27 March 2020
..., DNA repair and cell cycle transitions. The importance of the DDR is highlighted by the fact that DDR inactivation is commonly found in cancer and causes many different human diseases. The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators...
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Awards
Biochem Soc Trans (2019) 47 (6): 1609–1619.
Published: 12 December 2019
... of the Biochemical Society 2019 DNA damage DNA repair DNA-end synapsis double-strand breaks non-homologous end joining single-molecule methods Our human body is constantly challenged by the environment we live in, the lifestyle we choose and the medical treatments we need. DNA within the cells...
Articles
Biochem Soc Trans (2014) 42 (1): 82–88.
Published: 23 January 2014
...Nicola Curtin PARP-1 [poly(ADP-ribose) polymerase-1], which plays a key role in DNA repair, was discovered 50 years ago. PARPi (PARP inhibitors), originally made to probe the function of the enzyme, inhibit DNA repair and increase the potency of anticancer cytotoxic agents. PARPi of increasing...
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Biochem Soc Trans (2013) 41 (6): 1712–1719.
Published: 20 November 2013
... for the replicative helicase. Recent studies, however, indicate more diverse roles for Hsk1/Cdc7 in regulation of various chromosome dynamics, including initiation of meiotic recombination, meiotic chromosome segregation, DNA repair, replication checkpoints, centromeric heterochromatin formation and so forth. Hsk1...
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Biochem Soc Trans (2013) 41 (3): 777–782.
Published: 23 May 2013
.../licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. cell cycle chromatin chromodomain helicase DNA-binding 4 (CHD4) DNA damage DNA repair nucleosome remodelling and deacetylation (NuRD...
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Biochem Soc Trans (2012) 40 (2): 331–334.
Published: 21 March 2012
.... chromatin structure DNA repair nucleosome positioning nucleosome structure protein–DNA interaction Chromatin has a convoluted structure within the densely packed nucleus, but data from cross-linking experiments suggest that defined genes may be compartmentalized in clusters of co-ordinated...
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Biochem Soc Trans (2011) 39 (6): 1764–1769.
Published: 21 November 2011
... correspondence should be addressed (email zouy@etsu.edu ). 8 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair genome instability Hutchinson–Gilford progeria syndrome (HGPS) lamin A premature aging xeroderma pigmentosum group A (XPA) The aging...
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Biochem Soc Trans (2011) 39 (2): 413–423.
Published: 22 March 2011
... with partner proteins to participate in specific cellular functions. 1 email mark.dillingham@bristol.ac.uk 7 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA recombination DNA repair PcrA superfamily I helicase UvrD A DNA helicase is an enzyme...
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Biochem Soc Trans (2011) 39 (1): 111–115.
Published: 19 January 2011
... systems in M. maripaludis are an interesting mixture of eukaryotic and bacterial homologues and could provide a system for uncovering novel interactions between proteins from different domains of life. © The Authors Journal compilation © 2011 Biochemical Society 2011 archaeon DNA repair DNA...
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Biochem Soc Trans (2011) 39 (1): 140–144.
Published: 19 January 2011
... the enzyme engages with forked structures [ 3 , 6 ]. 29 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 Brr2 DNA repair Hel308 Mtr4 Prp43p The physiological role of Hel308 in archaea and eukaryotes is still far from clear, in part because of little...
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Biochem Soc Trans (2010) 38 (2): 433–437.
Published: 22 March 2010
... and related enzymes. DNA repair exonuclease-1 (EXO-1) flap endonuclease 1 (FEN-1) gap endonuclease 1 (GEN-1) metal ion xeroderma pigmentosum complementation group G (XPG) We thank Professor Jon Sayers and members of the Centre for Chemical Biology (Sheffield) and the Structural Cell Biology...
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Biochem Soc Trans (2010) 38 (2): 399–403.
Published: 22 March 2010
... of these enzymes is achieved. 1 email d.m.j.lilley@dundee.ac.uk 15 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 DNA repair genetic recombination Holliday junction molecular recognition nuclease Four-way DNA (Holliday) junctions [ 1...
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Biochem Soc Trans (2010) 38 (1): 116–131.
Published: 19 January 2010
... modifications and interactions that regulate nucleotide excision repair, translesion synthesis, double-strand break repair and interstrand cross-link repair, with the discussion of relevant examples in each pathway. DNA damage DNA repair phosphorylation small ubiquitin-related modifier (SUMO) ubiquitin...
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Biochem Soc Trans (2009) 37 (3): 479–481.
Published: 20 May 2009
..., sometimes these processes do not function correctly, leading to genome instability. Studies of DNA repair and genome instability and their causes and cures were showcased in the 2008 Biochemical Society Annual Symposium. The present article provides a summary of the talks given and the subsequent papers...
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Biochem Soc Trans (2009) 37 (3): 539–545.
Published: 20 May 2009
... ligase DNA repair Ku non-homologous end-joining (NHEJ) polymerase The crystal structures of a number of PolDoms have been elucidated, both as apo and nucleotide-bound forms ( Figure 3 A), which confirmed that these primases share significant structural homology with the replicative AEPs [ 13...
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Biochem Soc Trans (2009) 37 (3): 483–494.
Published: 20 May 2009
... Lakin, Oskar Fernandez-Capetillo and David Cortez at around the same time [ 70 – 72 ]. © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer cancer therapy cell cycle DNA damage DNA repair Although DNA within our cells is a relatively inert chemical...
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Biochem Soc Trans (2009) 37 (3): 605–613.
Published: 20 May 2009
... that are involved in many vital cellular processes (summarized in Figure 2 ). These include DNA replication proteins, proteins of DNA-repair machineries, cell-cycle regulators, chromatin remodelling and assembly factors, sister-chromatid cohesion proteins, transcription and translation factors, metabolic enzymes...
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Biochem Soc Trans (2009) 37 (1): 36–41.
Published: 20 January 2009
...Sabrina Fröls; Malcolm F. White; Christa Schleper Mechanisms involved in DNA repair and genome maintenance are essential for all organisms on Earth and have been studied intensively in bacteria and eukaryotes. Their analysis in extremely thermophilic archaea offers the opportunity to discover...
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Biochem Soc Trans (2008) 36 (5): 1071–1076.
Published: 19 September 2008
... correspondence should be addressed (email s.loft@pubhealth.ku.dk ). 30 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 base excision repair biomarker DNA damage DNA repair nucleotide excision repair oxidative damage Multiple exogenous and endogenous...
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Biochem Soc Trans (2007) 35 (6): 1519–1524.
Published: 23 November 2007
... To whom correspondence should be addressed (email j.a.downs@sussex.ac.uk ). 28 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chromatin DNA damage DNA repair H2AX variant histone H2A Chromatin is the term for DNA complexed with proteins that exists...
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Biochem Soc Trans (2006) 34 (5): 633–645.
Published: 25 October 2006
... of the homologous recombination machinery, whereas BRCA1 is an E3 ubiquitin ligase that has an impact on DNA repair, transcriptional regulation, cell-cycle progression and meiotic sex chromosome inactivation. In this article, I will review the most recent advances and provide a perspective of potential future...
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Biochem Soc Trans (2006) 34 (5): 764–769.
Published: 25 October 2006
... of immune signalling and the initiation of DNA repair. In addition, we look at the evidence implicating these enzymes in the pathogenesis of diseases such as cancer and neurodegenerative diseases. 1 To whom correspondence should be addressed (email jim.johnston@qub.ac.uk ). 10 8 2006 ©...
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Biochem Soc Trans (2005) 33 (6): 1471–1473.
Published: 26 October 2005
... 22 6 2005 © 2005 The Biochemical Society 2005 archaea DNA repair Hel308 helicase replication fork replication restart Origins of replication are the starting blocks firing genome duplication in all organisms. At origins, the co-ordinated actions of DNA loading proteins...
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Biochem Soc Trans (2004) 32 (6): 957–958.
Published: 26 October 2004
... cancer DNA repair helicase recombination topoisomerase The RecQ family of DNA helicases has received considerable interest due to their putative roles in suppression of cancer and premature ageing in humans [ 1 ]. Mutations in three different human RecQ helicase genes cause BS (Bloom's syndrome...
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Biochem Soc Trans (2004) 32 (6): 959–961.
Published: 26 October 2004
...H.E. Bryant; T. Helleday PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair is well documented. Many anticancer therapies work by inducing breaks in DNA, if unrepaired these can lead to cell death. As PARP promotes DNA...
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Biochem Soc Trans (2004) 32 (6): 962–963.
Published: 26 October 2004
... by immunoblotting with the indicated antibodies. Using HeLa WCE and a uracil hairpin substrate, we were able to cross-link several DNA repair proteins analysed, including Pol β (DNA polymerase β), DNA ligase IIIα–XRCC1 (X-ray cross-complementing protein 1) complex and poly(ADP-ribose) polymerase-1 (PARP-1...
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Biochem Soc Trans (2003) 31 (3): 706–710.
Published: 01 June 2003
... be addressed (e-mail thorsten.allers@nottingham.ac.uk ). Molecular Mechanisms and Manipulation in Archaea, a Biochemical Society-sponsored meeting held at The University of Nottingham, 30–31 January 2003 16 January 2003 © 2003 Biochemical Society 2003 Archaea DNA repair Haloferax...
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Biochem Soc Trans (2003) 31 (3): 690–693.
Published: 01 June 2003
... extensively as simpler models of the much more complex eukaryal ones. Archaeal DNA-repair pathways are not yet well characterized, and their relationship with repair pathways in bacteria and eukarya are still open to question. There are also strong distinctions between the major subdivisions crenarchaea...
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Biochem Soc Trans (2003) 31 (3): 699–702.
Published: 01 June 2003
... 2002 © 2003 Biochemical Society 2003 Archaea deoxyuridine-triphosphate pyrophosphatase DNA polymerase DNA repair uracil uracil-DNA glycosylase Abbreviations used: dUTPase, deoxyuridine-triphosphate pyrophophatase; UDGase, uracil-DNA glycosylase. Molecular Mechanisms...
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Biochem Soc Trans (2003) 31 (1): 40–44.
Published: 01 February 2003
... Copyright 2003 Biochemical Society 2003 DNA damage sensor DNA repair Abbreviations used: ATM, ataxia telangiectasiamutated protein; ATR, ataxia telangiectasia and Rad3-related protein; ATRIP, ATR-interacting protein; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent protein...
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Biochem Soc Trans (2001) 29 (6): 655–661.
Published: 01 November 2001
...@mole.bio.cam.ac.uk 9 7 2001 © 2001 Biochemical Society 2001 checkpoints DNA repair radiosensitivity ATM, ataxia telangiectasia mutated protein ATR, ataxia telangiectasia-related protein DNA-PKcs, DNA-dependent protein kinase catalytic subunit DSB, double-strand break HR, homologous...
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Biochem Soc Trans (2001) 29 (6): 661–666.
Published: 01 November 2001
...Y. Shiloh DNA damage is one of the most acute threats to cellular homeostasis and life. The cell responds to such damage by activating a vast array of responses, ranging from DNA repair to numerous signalling pathways, which temporarily slow down the cellular life cycle while the damage is being...
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Biochem Soc Trans (2001) 29 (2): 196–201.
Published: 01 May 2001
... correspondence should be addressed (e-mail m-jasin@ski.mskcc.org ) 3 11 2000 © 2001 Biochemical Society 2001 BRCAI DNA repair non-homologous end-joining sister chromatid tumorigenesis DSB, double-strand break HR, homologous recombination NHEJ, non-homologous end-joining...