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Keywords: DNA repair
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2359–2376.
Published: 10 December 2020
...Ekaterina Zabolotnaya; Ioanna Mela; Robert M. Henderson; Nicholas P. Robinson The bacterial SbcC/SbcD DNA repair proteins were identified over a quarter of a century ago. Following the subsequent identification of the homologous Mre11/Rad50 complex in the eukaryotes and archaea, it has become clear...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 677–691.
Published: 27 March 2020
..., DNA repair and cell cycle transitions. The importance of the DDR is highlighted by the fact that DDR inactivation is commonly found in cancer and causes many different human diseases. The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators...
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1609–1619.
Published: 12 December 2019
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 DNA damage DNA repair DNA-end synapsis double-strand breaks non-homologous end joining single-molecule methods Our human body is constantly challenged by the environment we live...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 82–88.
Published: 23 January 2014
...Nicola Curtin PARP-1 [poly(ADP-ribose) polymerase-1], which plays a key role in DNA repair, was discovered 50 years ago. PARPi (PARP inhibitors), originally made to probe the function of the enzyme, inhibit DNA repair and increase the potency of anticancer cytotoxic agents. PARPi of increasing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1712–1719.
Published: 20 November 2013
... for the replicative helicase. Recent studies, however, indicate more diverse roles for Hsk1/Cdc7 in regulation of various chromosome dynamics, including initiation of meiotic recombination, meiotic chromosome segregation, DNA repair, replication checkpoints, centromeric heterochromatin formation and so forth. Hsk1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 777–782.
Published: 23 May 2013
.../licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. cell cycle chromatin chromodomain helicase DNA-binding 4 (CHD4) DNA damage DNA repair nucleosome remodelling and deacetylation (NuRD) The CHD3...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 331–334.
Published: 21 March 2012
... correspondence should be addressed (email r.bowater@uea.ac.uk ). 13 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 chromatin structure DNA repair nucleosome positioning nucleosome structure protein–DNA interaction Eukaryotic chromatin has been the subject...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1764–1769.
Published: 21 November 2011
... correspondence should be addressed (email zouy@etsu.edu ). 8 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair genome instability Hutchinson–Gilford progeria syndrome (HGPS) lamin A premature aging xeroderma pigmentosum group A (XPA) The aging...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 413–423.
Published: 22 March 2011
... with partner proteins to participate in specific cellular functions. 1 email mark.dillingham@bristol.ac.uk 7 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA recombination DNA repair PcrA superfamily I helicase UvrD A DNA helicase is an enzyme...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 140–144.
Published: 19 January 2011
... correspondence should be addressed (email ed.bolt@nottingham.ac.uk ). 29 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 Brr2 DNA repair Hel308 Mtr4 Prp43p A recent review covered the discovery of hel308 from genetic analysis of its involvement in DNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 111–115.
Published: 19 January 2011
... 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 archaeon DNA repair DNA replication Methanococcales recombination The chimaeric nature of archaeal genomes has been commented on at some length. In general, the information-processing pathways...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 433–437.
Published: 22 March 2010
... and related enzymes. 1 To whom correspondence should be addressed (email j.a.grasby@sheffield.ac.uk ). 12 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 DNA repair exonuclease-1 (EXO-1) flap endonuclease 1 (FEN-1) gap endonuclease 1 (GEN-1) metal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 399–403.
Published: 22 March 2010
... of these enzymes is achieved. 1 email d.m.j.lilley@dundee.ac.uk 15 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 DNA repair genetic recombination Holliday junction molecular recognition nuclease Four-way DNA (Holliday) junctions [ 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 116–131.
Published: 19 January 2010
... 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 DNA damage DNA repair phosphorylation small ubiquitin-related modifier (SUMO) ubiquitin Cells have developed elaborate mechanisms for the rapid and sensitive sensing and repair of damaged DNA, collectively...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 479–481.
Published: 20 May 2009
..., sometimes these processes do not function correctly, leading to genome instability. Studies of DNA repair and genome instability and their causes and cures were showcased in the 2008 Biochemical Society Annual Symposium. The present article provides a summary of the talks given and the subsequent papers...
Articles
Janet Hall, Virginie Marcel, Celeste Bolin, Marie Fernet, Laurence Tartier, Laurence Vaslin, Pierre Hainaut
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 527–533.
Published: 20 May 2009
...Janet Hall; Virginie Marcel; Celeste Bolin; Marie Fernet; Laurence Tartier; Laurence Vaslin; Pierre Hainaut DNA-repair systems maintain the integrity of the human genome, and cell-cycle checkpoints are a critical component of the cellular response to DNA damage. Thus the presence of sequence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 539–545.
Published: 20 May 2009
... correspondence should be addressed (email ajd21@sussex.ac.uk ). 11 2 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 bacterium DNA ligase DNA repair Ku non-homologous end-joining (NHEJ) polymerase DSBs (double-strand breaks) in DNA represent a lethal form...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 483–494.
Published: 20 May 2009
... for treating cancer and provide an example of a DDR-inhibitory drug that is showing promise in clinical trials. 1 email s.jackson@gurdon.cam.ac.uk 16 1 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer cancer therapy cell cycle DNA damage DNA repair...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 605–613.
Published: 20 May 2009
... be addressed (email thomas.helleday@rob.ox.ac.uk ). 9 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer chromatin modification DNA repair DNA replication proliferating-cell nuclear antigen (PCNA) replication fork The accurate transmission...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 36–41.
Published: 20 January 2009
...Sabrina Fröls; Malcolm F. White; Christa Schleper Mechanisms involved in DNA repair and genome maintenance are essential for all organisms on Earth and have been studied intensively in bacteria and eukaryotes. Their analysis in extremely thermophilic archaea offers the opportunity to discover...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1071–1076.
Published: 19 September 2008
... correspondence should be addressed (email s.loft@pubhealth.ku.dk ). 30 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 base excision repair biomarker DNA damage DNA repair nucleotide excision repair oxidative damage Multiple exogenous and endogenous...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1519–1524.
Published: 23 November 2007
... To whom correspondence should be addressed (email j.a.downs@sussex.ac.uk ). 28 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chromatin DNA damage DNA repair H2AX variant histone H2A Chromatin is the term for DNA complexed with proteins that exists...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 633–645.
Published: 25 October 2006
... of the homologous recombination machinery, whereas BRCA1 is an E3 ubiquitin ligase that has an impact on DNA repair, transcriptional regulation, cell-cycle progression and meiotic sex chromosome inactivation. In this article, I will review the most recent advances and provide a perspective of potential future...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 764–769.
Published: 25 October 2006
... of immune signalling and the initiation of DNA repair. In addition, we look at the evidence implicating these enzymes in the pathogenesis of diseases such as cancer and neurodegenerative diseases. 1 To whom correspondence should be addressed (email jim.johnston@qub.ac.uk ). 10 8 2006 ©...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1471–1473.
Published: 26 October 2005
... and/or in replication-restart pathways. As described here, these may be relevant to understanding genome instability in metazoans. 22 6 2005 © 2005 The Biochemical Society 2005 archaea DNA repair Hel308 helicase replication fork replication restart Origins of replication...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 957–958.
Published: 26 October 2004
... BLM cancer DNA repair helicase recombination topoisomerase ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 959–961.
Published: 26 October 2004
...H.E. Bryant; T. Helleday PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair is well documented. Many anticancer therapies work by inducing breaks in DNA, if unrepaired these can lead to cell death. As PARP promotes DNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 962–963.
Published: 26 October 2004
.... This approach provides us with information as to which proteins were involved and when they are engaged during BER. base excision repair DNA polymerase β DNA repair X-ray cross-complementing protein 1 (XRCC1) Using HeLa WCE and a uracil hairpin substrate, we were able to cross-link several DNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 699–702.
Published: 01 June 2003
... 2002 © 2003 Biochemical Society 2003 Archaea deoxyuridine-triphosphate pyrophosphatase DNA polymerase DNA repair uracil uracil-DNA glycosylase Abbreviations used: dUTPase, deoxyuridine-triphosphate pyrophophatase; UDGase, uracil-DNA glycosylase. Molecular Mechanisms...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 706–710.
Published: 01 June 2003
... be addressed (e-mail thorsten.allers@nottingham.ac.uk ). Molecular Mechanisms and Manipulation in Archaea, a Biochemical Society-sponsored meeting held at The University of Nottingham, 30–31 January 2003 16 January 2003 © 2003 Biochemical Society 2003 Archaea DNA repair Haloferax...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 690–693.
Published: 01 June 2003
... extensively as simpler models of the much more complex eukaryal ones. Archaeal DNA-repair pathways are not yet well characterized, and their relationship with repair pathways in bacteria and eukarya are still open to question. There are also strong distinctions between the major subdivisions crenarchaea...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 40–44.
Published: 01 February 2003
... ) Copyright 2003 Biochemical Society 2003 DNA damage sensor DNA repair Abbreviations used: ATM, ataxia telangiectasiamutated protein; ATR, ataxia telangiectasia and Rad3-related protein; ATRIP, ATR-interacting protein; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (6): 655–661.
Published: 01 November 2001
...@mole.bio.cam.ac.uk 9 7 2001 © 2001 Biochemical Society 2001 checkpoints DNA repair radiosensitivity ATM, ataxia telangiectasia mutated protein ATR, ataxia telangiectasia-related protein DNA-PKcs, DNA-dependent protein kinase catalytic subunit DSB, double-strand break HR, homologous...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (6): 661–666.
Published: 01 November 2001
...Y. Shiloh DNA damage is one of the most acute threats to cellular homeostasis and life. The cell responds to such damage by activating a vast array of responses, ranging from DNA repair to numerous signalling pathways, which temporarily slow down the cellular life cycle while the damage is being...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 196–201.
Published: 01 May 2001
... correspondence should be addressed (e-mail m-jasin@ski.mskcc.org ) 3 11 2000 © 2001 Biochemical Society 2001 BRCAI DNA repair non-homologous end-joining sister chromatid tumorigenesis DSB, double-strand break HR, homologous recombination NHEJ, non-homologous end-joining...
