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Keywords: DNA polymeraseClose
Biochem Soc Trans (2016) 44 (5): 1427–1440.
Published: 19 October 2016
... of the Biochemical Society 2016 DNA polymerase retrovirus RNA chaperones Retroviruses constitute a large family of small enveloped plus-strand RNA viruses ( Figure 1A ) that are widespread in eukaryotes and can cause cancer, immunodeficiency and neurological disorder in human and animals [ 1 – 4...
Biochem Soc Trans (2011) 39 (2): 595–599.
Published: 22 March 2011
...Joshua P. Gill; Jun Wang; David P. Millar DNA polymerases are essential enzymes responsible for replication and repair of DNA in all organisms. To replicate DNA with high fidelity, DNA polymerases must select the correct incoming nucleotide substrate during each cycle of nucleotide incorporation...
Biochem Soc Trans (2010) 38 (1): 110–115.
Published: 19 January 2010
... evolved accurate machineries to ensure faithful replication of the DNA genome. Replicative DNA polymerases are characteristic for their high processivity and high fidelity which are achieved by their stringent active sites and the 3′→5′ proofreading exonuclease activity. DNA, however, is constantly...
Biochem Soc Trans (2009) 37 (1): 65–68.
Published: 20 January 2009
...Bernard A. Connolly Archaeal family-B DNA polymerases interact specifically with uracil and hypoxanthine, stalling replication on encountering these deaminated bases in DNA template strands. The present review describes X-ray structural data which elucidate the mechanism of read-ahead recognition...
Biochem Soc Trans (2004) 32 (2): 240–244.
Published: 01 April 2004
... enzyme, has a novel domain, termed prim/pol domain. This domain constitutes the first member of the DNA polymerase family E. Based on the biochemical characterization of the gene products a model of how pRN1 is replicated in vivo is proposed. 240 Biochemical Society Transactions (2004) Volume 32, part...
Biochem Soc Trans (2003) 31 (3): 699–702.
Published: 01 June 2003
...B.A. Connolly; M.J. Fogg; G. Shuttleworth; B.T. Wilson Archaeal family-B DNA polymerases possess a novel uracil-sensing mechanism. A specialized pocket scans the template, ahead of the replication fork, for the presence of uracil; on encountering this base, DNA synthesis is stalled. The structural...