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Keywords: DNA methylation
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Articles
Biochem Soc Trans (2022) 50 (6): 1875–1884.
Published: 01 December 2022
... form stable left-handed Z-DNA structures. The protein that carries out this function is identified as ZBTB43, member of a large family of ZBTB proteins. Z-DNA remodeling by ZBTB43 not only coincides with global remodeling of DNA methylation and chromatin events in the male germ line, but it also...
Articles
Biochem Soc Trans (2022) 50 (2): 723–736.
Published: 14 March 2022
... of DNA methylation to their transcriptional regulation [ 65 ]. A compelling example of a Pol III-transcribed gene that is epigenetically regulated by CpG methylation is nc886, whose dysregulated methylation may contribute to different types of cancer [ 51 , 66 ]. The evolutionary origin of most...
Articles
Biochem Soc Trans (2021) 49 (3): 1109–1119.
Published: 22 June 2021
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . chromatin CpG islands DNA methylation orphan CpG islands CpG islands (CGIs) represent a pervasive DNA sequence class frequently associated with vertebrate gene promoters...
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Biochem Soc Trans (2021) 49 (3): 1159–1170.
Published: 01 June 2021
... and the Biochemical Society under a transformative agreement with CAUL. chromatin reader DNA methylation gene repression histone modifications polycomb repressive complex 2 PRC2 Chromatin structure and epigenetic context are crucial regulatory factors for gene expression in eukaryotes. Chromatin...
Articles
Biochem Soc Trans (2019) 47 (4): 997–1003.
Published: 18 July 2019
...Huiming Zhang; Kang Zhang; Jian-Kang Zhu DNA methylation at the fifth position of cytosine is a major epigenetic mark conserved in plants and mammals. Genome-wide DNA methylation patterns are dynamically controlled by integrated activities of establishment, maintenance, and removal. In both plants...
Articles
Biochem Soc Trans (2018) 46 (5): 1191–1202.
Published: 28 August 2018
...Humaira Gowher; Albert Jeltsch As part of the epigenetic network, DNA methylation is a major regulator of chromatin structure and function. In mammals, it mainly occurs at palindromic CpG sites, but asymmetric methylation at non-CpG sites is also observed. Three enzymes are involved...
Articles
Biochem Soc Trans (2013) 41 (3): 697–699.
Published: 23 May 2013
... compilation © 2013 Biochemical Society 2013 acetylation DNA methylation epigenetics histone hydoxymethylation Epigenetics is the study of changes in gene expression which occur in the absence of mutation, but are mitotically inheritable. Epigenetics was first put forward as an idea...
Articles
Biochem Soc Trans (2013) 41 (3): 727–740.
Published: 23 May 2013
...-modifying activities that are thought to contribute to transcriptional repression and maintain heterochromatic regions of the genome. In contrast with DNA methylation, which is found broadly across vertebrate genomes, non-methylated DNA is concentrated in regions known as CGIs (CpG islands). Recently...
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Articles
Biochem Soc Trans (2013) 41 (3): 809–814.
Published: 23 May 2013
...Catherine M. Rose; Sander van den Driesche; Richard R. Meehan; Amanda J. Drake Epigenetic reprogramming of germ cells involves the genome-wide erasure and subsequent re-establishment of DNA methylation, along with reprogramming of histone modification profiles and the eventual incorporation...
Articles
Biochem Soc Trans (2008) 36 (4): 575–583.
Published: 22 July 2008
... from model systems shows that MeCP2 can recruit the Sin3a co-repressor complex to promoters leading to transcriptional repression, therefore suggesting that MeCP2 can interpret the DNA methylation signal to bring about gene silencing. Mutations in the human MECP2 gene cause the autism spectrum disorder...
Articles
Biochem Soc Trans (2007) 35 (3): 618–622.
Published: 22 May 2007
..., through DNA methylation and chromatin-based mechanisms. Their activation and silencing indicates a change in the epigenetic state of the genome. The thousands of endogenous retro-elements in the mouse genome provides potential scope for large-scale co-ordinated epigenetic fluctuations and leads...
Articles
Biochem Soc Trans (2007) 35 (2): 331–335.
Published: 20 March 2007
...R.G. Schipper; L.P. van den Heuvel; A.A.J. Verhofstad; R.A. De Abreu Both polyamine metabolism and DNA methylation play an important role in normal and malignant growth. Specific enzyme inhibitors or drugs that interfere with these metabolic pathways have proven to be potential anticancer agents...
Articles
Biochem Soc Trans (2005) 33 (6): 1537–1540.
Published: 26 October 2005
...J. Berger; A. Bird DNA methylation is an epigenetic mechanism involved in transcriptional silencing of imprinted genes, genes located on the inactive X chromosome, and a number of tumour suppressor genes in cancer. MBD (methyl-CpG-binding domain) proteins selectively bind to methylated DNA...
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Articles
Biochem Soc Trans (2004) 32 (6): 1006–1007.
Published: 26 October 2004
...J.A. McKay; E.A. Williams; J.C. Mathers DNA methylation is one of several epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging...
Articles
Biochem Soc Trans (2004) 32 (6): 946–951.
Published: 26 October 2004
... undergone expansion and evidence exists for multiple RNA silencing pathways. Recent progress in defining the components of a number of these pathways is examined here. 23 6 2004 © 2004 The Biochemical Society 2004 Dicer DNA methylation miRNA RNA-induced silencing complex (RISC) siRNA...
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Biochem Soc Trans (2004) 32 (6): 1095–1097.
Published: 26 October 2004
...J.A. Plumb; N. Steele; P.W. Finn; R. Brown Histone deacetylation and DNA methylation have a central role in the control of gene expression, including transcriptional repression of tumour suppressor genes. Loss of DNA mismatch repair due to methylation of the hMLH1 gene promoter results...
Articles
Biochem Soc Trans (2004) 32 (6): 913–915.
Published: 26 October 2004
...G. Strathdee; A. Sim; R. Brown The role of DNA methylation in the control of mammalian gene expression has been the subject of intensive research in recent years, partly due to the critical role of CpG island methylation in the inactivation of tumour suppressor genes during the development...