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Biochem Soc Trans (2018) 46 (5): 1171–1182.
Published: 06 September 2018
...Stephen E. Harding; Guy Channell; Mary K. Phillips-Jones We recall the experimental approaches involved in the discovery of hydrogen bonds in deoxyribonucleic acid (DNA) made 70 years ago by a team of scientists at University College Nottingham led by J.M. Gulland, and in relation to previous...
Biochem Soc Trans (2018) 46 (3): 729–740.
Published: 05 June 2018
...Lucien E. Weiss; Tal Naor; Yoav Shechtman The structural organization and dynamics of DNA are known to be of paramount importance in countless cellular processes, but capturing these events poses a unique challenge. Fluorescence microscopy is well suited for these live-cell investigations...
Biochem Soc Trans (2017) 45 (5): 1159–1171.
Published: 12 September 2017
...Alicia K. Byrd; Kevin D. Raney Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial DNA in eukaryotes. Saccharomyces cerevisiae Pif1 is involved in replication through barriers to replication, such as G-quadruplexes and protein blocks, and reduces genetic...
Biochem Soc Trans (2013) 41 (2): 491–493.
Published: 21 March 2013
...Andrzej Stasiak; Andrew D. Bates; Dorothy E. Buck; Sarah A. Harris; De Witt Sumners The Topological Aspects of DNA Function and Protein Folding international meeting provided an interdisciplinary forum for biological scientists, physicists and mathematicians to discuss recent developments...
Biochem Soc Trans (2013) 41 (2): 635–638.
Published: 21 March 2013
...Gregory S. Chirikjian The present mini-review covers the local and global geometry of framed curves and the computation of twist and writhe in knotted DNA circles. Classical inequalities relating the total amount of bending of a closed space curve and associated knot parameters are also explained...
Biochem Soc Trans (2012) 40 (4): 635–639.
Published: 20 July 2012
... is a brief account of the recent developments in QD–NA (nucleic acid), particularly NA aptamer, conjugate-based biosensors using the FRET (Förster resonance energy transfer) readout mechanism. It starts with a brief introduction to the NA aptamer and QD-FRET, followed by example approaches to compact QD–DNA...
Includes: Supplementary data
Biochem Soc Trans (2012) 40 (2): 357–363.
Published: 21 March 2012
...Wallace H. Liu; Mair E.A. Churchill The eukaryotic processes of nucleosome assembly and disassembly govern chromatin dynamics, in which histones exchange in a highly regulated manner to promote genome accessibility for all DNA-dependent processes. This regulation is partly carried out by histone...
Biochem Soc Trans (2011) 39 (2): 575–580.
Published: 22 March 2011
...Marvin H. Caruthers Current methodologies used to synthesize DNA and RNA are reviewed. These focus on using controlled pore glass and microarrays on glass slides. It is clear that synthetic DNAs, and more recently RNAs, have become indispensable tools for achieving major advances in biology...
Biochem Soc Trans (2010) 38 (2): 381–383.
Published: 22 March 2010
...W. Marshall Stark; Ben F. Luisi; Richard P. Bowater As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery...
Biochem Soc Trans (2009) 37 (2): e1–e4.
Published: 06 May 2009
... in Nucleic Acid Detection and Quantification’, and the primary aim was to bring together scientists from different disciplines who nevertheless are trying to develop reliable methods for the quantification or detection of RNA and DNA molecules. This meant that physical and organic chemists, microbial...
Biochem Soc Trans (2008) 36 (4): 732–737.
Published: 22 July 2008
...Remus Th. Dame Architectural proteins play a key role in the folding, organization and compaction of genomic DNA in all organisms. By bending, bridging or wrapping DNA, these proteins ensure that its effective volume is reduced sufficiently to fit inside the cell or a dedicated cellular organelle...
Biochem Soc Trans (2007) 35 (2): 369–373.
Published: 20 March 2007
... ( N 1 , N 12 -diethyl-1,12-diamino-3,6,9-triazadodecane) are described. Possible applications of SpmTrien and its derivatives to the investigation of the enzymes of polyamine metabolism and spermine cellular functions, including interaction with DNA, are discussed. A second approach...
Biochem Soc Trans (2004) 32 (6): 916–917.
Published: 26 October 2004
...J.M. Teodoridis; G. Strathdee; J.A. Plumb; R. Brown Aberrant methylation of CpG islands (CpG-rich regions of DNA associated with the promoters of many genes) is associated with transcriptional inactivation of genes involved in tumour development. Genes involved in key DNA damage response pathways...
Biochem Soc Trans (2004) 32 (6): 964–966.
Published: 26 October 2004
...C.E. West; W.M. Waterworth; P.A. Sunderland; C.M. Bray DSBs (double-strand breaks) are one of the most serious forms of DNA damage that can occur in a cell's genome. DNA replication in cells containing DSBs, or following incorrect repair, may result in the loss of large amounts of genetic material...
Biochem Soc Trans (2003) 31 (6): 1341–1342.
Published: 01 December 2003
... in certain diseases. Improved understanding of the balance between glycation and the enzymatic anti-glycation defence will advance disease diagnosis and therapy. amadoriase DNA glycation glyoxalase phospholipid protein 1 e-mail firstname.lastname@example.org 679th Meeting of the Biochemical...
Biochem Soc Trans (2003) 31 (5): 893–905.
Published: 01 October 2003
... nucleosomes are relocated varies. Mounting evidence supports the ability of remodelling enzymes to translocate along DNA. This provides a means by which they could alter both the twist and writhe of DNA on the surface of nucleosomes, and so accelerate nucleosome repositioning. 1 e-mail t.a.owenhughes...