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Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1885–1895.
Published: 13 December 2022
... and inhibitors of the molecule have been proposed for anti-cancer clinical applications. eIF5A is the only protein in the cell that contains the post-translational modification hypusine. Hypusination is a two-step enzymatic process catalysed by the Deoxyhypusine Synthase (DHPS) and Deoxyhypusine Hydroxylase...