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Keywords: Cryo-EM
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Articles
Biochem Soc Trans (2023) 51 (6): 2041–2059.
Published: 28 November 2023
... electron microscopy (Cryo-EM). Moreover, this approach offers a powerful platform for correlative microscopy. Another key advantage of Cryo-LM is the strong reduction in photobleaching at low temperatures, facilitating the collection of orders of magnitude more photons from a single fluorophore...
Articles
Biochem Soc Trans (2023) 51 (4): 1701–1711.
Published: 10 August 2023
...Miles Graham; Peijun Zhang Developments in cryo-electron microscopy (cryo-EM) have been interwoven with the study of viruses ever since its first applications to biological systems. Following the success of single particle cryo-EM in the last decade, cryo-electron tomography (cryo-ET) is now...
Articles
Biochem Soc Trans (2023) 51 (3): 1347–1360.
Published: 02 June 2023
... by the technological advancements in cryo-EM analysis, which has elucidated many new P-type ATPase structures and mechanisms and revealed several new ways of regulation. In this review, we highlight the progress of the field and focus on special features that are present in the five subfamilies. Hence, we outline...
Articles
Biochem Soc Trans (2023) 51 (1): 427–434.
Published: 25 January 2023
... studies in recent years provide in-depth understanding of how the MLL1 and homologous yeast SET1 complexes interact with the nucleosome core particle (NCP) and how their activities for H3K4 methylation are regulated by the conserved core components. Here, we will discuss the recent single molecule cryo-EM...
Articles
Biochem Soc Trans (2022) 50 (6): 1953–1962.
Published: 16 December 2022
... in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. actin cryo-EM lumen microtubule tomography Microtubules are essential for a vast range of cellular processes, acting both as a dynamic...
Articles
Biochem Soc Trans (2022) 50 (6): 1763–1772.
Published: 23 November 2022
... Mancia ( fm123@cumc.columbia.edu ) 20 9 2022 3 11 2022 7 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cryo-EM membrane proteins palmitoleation WLS Wnt proteins Wnts are short-range signaling proteins...
Articles
Biochem Soc Trans (2022) 50 (1): 231–239.
Published: 22 February 2022
... these, the electron cryomicroscopy (cryo-EM) method microcrystal electron diffraction (MicroED) has produced atomic resolution structures of important biological and small molecules. Since its inception in 2013, MicroED established a demonstrated ability for solving structures of difficult samples using vanishingly...
Articles
Biochem Soc Trans (2022) 50 (1): 309–320.
Published: 07 February 2022
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chromatin CMG cryo-EM Ctf18 Pol epsilon replisome In all replicating systems a hexameric, ring-shaped helicase is loaded around DNA and uses the energy derived from nucleotide hydrolysis to unwind the double helix...
Articles
Biochem Soc Trans (2021) 49 (6): 2627–2638.
Published: 23 November 2021
...Joshua A. Lees; Joao M. Dias; Seungil Han Electron cryo-microscopy (cryo-EM) is a powerful technique for the structural characterization of biological macromolecules, enabling high-resolution analysis of targets once inaccessible to structural interrogation. In recent years, pharmaceutical...
Articles
Biochem Soc Trans (2021) 49 (5): 1927–1939.
Published: 08 October 2021
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. cryo-EM human telomerase telomeres In the 1930s, the natural ends of chromosomes were independently discovered in maize and fruit flies by McClintock and Muller, respectively [ 1–3 ]. Unlike DNA breaks...
Articles
Biochem Soc Trans (2019) 47 (1): 399–410.
Published: 07 February 2019
..., Middle and Tail, was published in 1999. Within the last few years, optimization of Mediator purification combined with technical and methodological advances in cryo-electron microscopy (cryo-EM) have revealed unprecedented details of Mediator subunit organization, interactions with RNA polymerase II...
Includes: Supplementary data
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Biochem Soc Trans (2019) 47 (1): 281–293.
Published: 15 January 2019
... adoption of cryo-EM is the expansion of protein target classes for which structural information can drive project decisions, either through an improved mechanistic understanding of disease biology or through high-quality atomistic experimental models of ligand–protein complexes. Perhaps, the best example...
Articles
Biochem Soc Trans (2016) 44 (3): 851–855.
Published: 09 June 2016
... of the rotor. Figure 2 Subunit interactions about the collar region of the V-ATPase in 3 different conformational states Surface representations of collar subunits based on yeast cryo-EM structures for three rotational states [protein data bank (PDB): 3J9T, 3J9U, 3J9V] showing interactions between...
Articles
Biochem Soc Trans (2016) 44 (2): 534–540.
Published: 11 April 2016
... implications, with special emphasis on the emerging contributions of cryo-ET. 1 email ruben@biochem.mpg.de 15 1 2016 © 2016 Authors; published by Portland Press Limited 2016 cryo-EM extended-synaptotagmin lipid transfer Orai ryanodine receptor STIM Compartmentalization...