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Keywords: Cre/loxP
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Biochem Soc Trans (2005) 33 (6): 1534–1536.
Published: 26 October 2005
..., thereby preventing analyses of the heterozygous phenotype. Some of the limitations associated with generating ubiquitous gene knockouts have been circumvented by the use of the Cre/ loxP system. In this system, loxP elements are inserted into the genome, through homologous recombination in ES cells...